The Role of Phenytoin for Treatment of Enterocutan Fistula in Wistar Rat| Chapter 3 | Current Overview on Disease and Health Research Vol. 11

 Introduction: Enterocutanean fistula (ECF) is a difficult intestinal question; even though willing closure happens 90% of moment of truth, it takes nearly 5 weeks. Phenytoin was guide faster pancreatic and enterocutaneous fistula composition. To purify the system of the restorative effect of phenytoin on ECF, animal research will make public.Methods: The width of the ECF, the number of fibroblasts, angiogenesis, the number (percentage) of collagen, the tickness of granulation fabric, and the number of lymphocytes were calculated in a randomized reserved trial equating the ECF of Wistar rats doctored accompanying a blend of depressed-measure phenytoin and source of nourishment C to phenytoin (oral and current) or source of nourishment C unique to a fake pill.Results: The width of the ECF was considerably (p< 0.05) weakened subsequently extreme-application phenytoin treatment and a merger of reduced-shot phenytoin and source of nourishment C. High-lot phenytoin or a alliance of reduced-measurement phenytoin and Vit C raised the number of fibroblasts, allotment or number of colagen, granulation tissue density, and angiogenesis while declining the number of lymphocytes (p 0.05).Conclusion: High-measurement phenytoin or depressed-dosage phenytoin linked accompanying source of nourishment C expedites ECF plug by increasing fibrosis, collagen, angiogenesis, and granulation fabric while declining lymphocytes .

Author(s) Details:

Sigit Adi Prasetyo,
Department of Surgery, Diponegoro Medical Faculty, Diponegoro University Semarang, Indonesia.

Victor Kurniawan,
Diponegoro University Semarang, Indonesia.

Budiman Irphan,
Diponegoro University Semarang, Indonesia.

Yohanes Sugiarto,
Diponegoro University Semarang, Indonesia.

Iwan Saragih,
Diponegoro University Semarang, Indonesia.

Gede Pambudi,
Diponegoro University Semarang, Indonesia.

Trilaksono Nugroho,
Department of Pharamacology, Diponegoro Medical Faculty, Diponegoro University Semarang, Indonesia.

. Hardian,
Department of Physiology, Diponegoro University Semarang, Indonesia.

. Hermawan,
Department of Pathology, Faculty of Medicine, Diponegoro University Semarang, Indonesia.

Ignatius Riwanto,
Department of Surgery, Diponegoro Medical Faculty, Diponegoro University Semarang, Indonesia.

Please see the link here: https://stm.bookpi.org/CODHR-V11/article/view/9286

A Rare Association of Skin Adverse Reaction to Phenytoin| Chapter 8 | Current Innovations in Medicine and Medical Science Vol. 10

 Phenytoin is a usually used anticonvulsant drug in children and persons for tonic clonic and biased seizures with common aftereffects like nausea, stomach pain, loss of appetite, wax hypertrophy etc. We encountered a patient 34-year-traditional male who bestowed with history of individual episode of convulsion, for that he was prescribed Tab Phenytoin 100mg double daily by oral route. After 15 days he grown rash over trunk which contaminate the whole carcass in two days associated with itching and climbing. There was no familial or personal history of drug aversion or skin conditions. Physical examination revealed diversified, purpuric macules and papules mainly on the body with scaling. Patient was acknowledged and subjected to investigations, that showed common report. Tab Phenytoin was withdrawn and Tab Prednisolone 40mg orally day-to-day was given and tapered by 10mg already in 15 days during that the lesions slowly showed bettering. Symptoms resolved completely in 2 weeks following in position or time phenytoin withdrawal and no adverse follow-up reported. Thus the same case presentation exhibits a rare antagonistic effect of phenytoin on skin.

Author(s) Details:

S. Suma,
Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.

K. Tejashwini,
Cognizant Technology Solutions, Mysore, Karnataka, India.

V. Hari Prasad,
Department of Forensic Medicine, Panimalar Medical College and Hospital, Chennai, India.

Please see the link here: https://stm.bookpi.org/CIMMS-V10/article/view/8868