Recently, 1,2,3-triazoles and quinoline have drawn a lot of attention due to their biological relevance. Through molecular hybridization, so-called 1,2,3-triazole-based quinolines, which create a single molecular framework with quinoline and triazole rings, provide an appropriate path to novel pharmacological medicines with powerful biological properties. In order to better understand the physicochemical characteristics of triazole-quinoline hybrids and create new bioactive chemical entities, the chemistry and biology of a number of 1,2,3-triazole-containing quinoline hybrids are covered in this chapter. As a consequence, the principal Lipinski parameters are briefly reviewed and applied to a few 1,2,3-triazole-quinoline hybrids, along with an in-silico study. The synthesis of the hybrids using Cu-catalyzed azide-alkyne cycloaddition technology and their pharmacological characteristics are the two components of this chapter. with an emphasis on widespread hazardous conditions including cancer, malaria, and human fungi infections.
Leonor Y. Vargas-Méndez,
Laboratorio de Química Orgánica y Biomolecular, Universidad Industrial de Santander, Bucaramanga, Colombia.
Vladimir V. Kouznetsov,
Laboratorio de Química Orgánica y Biomolecular, Universidad Industrial de Santander, Bucaramanga, Colombia.
Please see the link here: https://stm.bookpi.org/CTCB-V3/article/view/7501
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