The goal of the study was to look at the effects of gold nanoparticles (AuNP) on the male rat reproductive system, as well as the influence of cerium dioxide nanoparticles (CeO2NP) on the testes and fertility in ageing male rats, using xenografts and cell culture models. The presence of a polydispersed colloidal AuNP (10-50 nm) solution in the LNCaP culture medium at a final concentration of 10 g/ml hindered cell development, whereas a monodispersed AuNP (20 nm) solution had no effect. When delivered parenterally at doses ranging from 0.64-6.4 g/kg b.w., the polydispersed colloidal AuNP solution stopped the growth of human PCa xenografts in mice. On histological preparations of the xenografts, the selectivity of the nanopreparations effect on the prostate malignant epithelium is proven by its destruction and a decrease in the epithelial-stromal ratio. When supplied for up to two weeks, polydispersed and monodispersed AuNP solutions had no effect on the testes and accessory sexual glands of rats. The effect of a low dose of CeO2NP (1 mg/kg b.w.) given orally on testosterone secretion and spermatogenesis, as well as proliferative and secretory processes in the prostate of ageing male rats, was discovered. However, due to the immaturity of a portion of the spermatozoa, the fertility of the animals was lowered in contrast to the control group. To assess their therapeutic potential and toxicity, more research is needed into the mechanisms of metal nanoparticles and their salts' stimulating or destructive effects on normal and malignant tissues.
Author(s) Details:
A. G. Reznikov,
V. P. Komisarenko Institute of Endocrinology and Metabolism, National
Academy of Medical Sciences of Ukraine, 69 Vyshgorodska Str., Kiev, 04114,
Ukraine.
O. A. Faliush,
V. P. Komisarenko Institute of Endocrinology and Metabolism, National Academy
of Medical Sciences of Ukraine, 69 Vyshgorodska Str., Kiev, 04114, Ukraine.
N. D. Nosenko,
V. P. Komisarenko Institute of Endocrinology and Metabolism, National Academy
of Medical Sciences of Ukraine, 69 Vyshgorodska Str., Kiev, 04114, Ukraine.
O. V. Sachynska,
V. P. Komisarenko Institute of Endocrinology and Metabolism, National Academy
of Medical Sciences of Ukraine, 69 Vyshgorodska Str., Kiev, 04114, Ukraine.
L. I. Polyakova,
V. P. Komisarenko Institute of Endocrinology and Metabolism, National Academy
of Medical Sciences of Ukraine, 69 Vyshgorodska Str., Kiev, 04114, Ukraine.
A. A. Limareva,
V. P. Komisarenko Institute of Endocrinology and Metabolism, National Academy
of Medical Sciences of Ukraine, 69 Vyshgorodska Str., Kiev, 04114, Ukraine.
I. G. Perchyk,
V. P. Komisarenko Institute of Endocrinology and Metabolism, National Academy
of Medical Sciences of Ukraine, 69 Vyshgorodska Str., Kiev, 04114, Ukraine.
Please see the link here: https://stm.bookpi.org/IDMMR-V11/article/view/6078
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