Key Markers and Epigenetic Modifications of Dental-derived Mesenchymal Stromal Cells: A Review | Chapter 8 | Emerging Trends in Disease and Health Research Vol.4.

 The oral cavity has a diverse population of mesenchymal stromal cells (MSCs). Dental-derived MSCs-based approaches have shown significant potential among regeneration therapies. Dental-derived MSCs have been used in several preclinical investigations and clinical trials for the treatment of dental and non-dental diseases including as neurodegenerative diseases, autoimmune diseases, and orthopaedic problems. Dental-derived MSCs, on the other hand, vary in their origin tissues, individual donors, clonal subpopulations, and single cells. Variation in regeneration potential across cells in dental-derived MSCs cultures could skew trial outcomes and stymie or halt the adoption of dental-derived MSCs therapy in clinical practise. Although variation is unavoidable, our limited ability to detect and manage heterogeneity makes manufacturing dental-derived MSCs therapies difficult. We initially explored the heterogeneity of dental-derived MSCs before moving on to the important markers and epigenetic alterations associated with dental-derived MSC proliferation, differentiation, immunomodulation, and ageing. These messages aid in the regulation of the composition and function of dental-derived MSCs, allowing cell therapy to be more quickly implemented in clinical practise.

Author(s) Details:

Jingqiu Chen,
Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.


Xiaodan Zheng,
Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.


Nanquan Rao,
a Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.


Yao Huang,
Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.


Juan Liu,
Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.


Yanhong Li,
Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.


Jun Zhang,
Yunnan Provincial Key Laboratory of Stomatology, The Affiliated Stomatology Hospital of Kunming Medical University, Kunming, Yunnan, China.

Please see the link here: https://stm.bookpi.org/ETDHR-V4/article/view/6051