Erythropoietic Protoporphyria (EPP) is a condition defined by the buildup of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin due to ferrochelatase insufficiency. Severe hepatic failure and cholestasis were seen in some patients. In mice, griseofulvin (Gris) causes an experimental EPP with hepatic symptoms such as PROTO IX buildup, cellular damage, necrotic and inflammatory processes. Antioxidant defences were also tampered with. In a mouse model of EPP, the researchers wanted to see if different antioxidants like Trolox (Tx), Ascorbic acid (Asc), the combination of Tx and Asc, Melatonin (Mel), and polyphenols like Elagic acid, Quercetin, Chlorogenic acid, Caffeic acid, Galic acid, and Ferulic acid could protect heme biosynthesis, liver damage, and oxidative stress markers.
The heme biosynthetic pathway was primarily affected by coadministration of Gris with Tx, Asc, and their combinations, or Mel, resulting in a decrease in 5-aminolevulinic acid synthetase activity, which was increased by Gris, while the tested polyphenols had an anti-oxidant effect, decreasing lipid peroxidation and the activity of some antioxidant enzymes.
Finally, antioxidant agents can only partially protect against Gris-induced liver damage by lowering oxidative stress or acting on heme control.
Author(s) Details:
M. del C. Martínez,
Departamento de Química Biológica, Facultad de Ciencias Exactas y
Naturales, Universidad de Buenos Aires, Argentina. and Centro de
Investigaciones sobre Porfirinas y Porfirias (CIPYP), Universidad de Buenos
Aires-Consejo Nacional de Investigaciones Científicas y Tecnológicas, Hospital
de Clínicas José de San Martín, Argentina.
S. G. Afonso,
Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), Universidad de
Buenos Aires-Consejo Nacional de Investigaciones Científicas y Tecnológicas,
Hospital de Clínicas José de San Martín, Argentina.
A. Batlle,
Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), Universidad
de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Tecnológicas,
Hospital de Clínicas José de San Martín, Argentina.
A. M. Buzaleh,
Departamento de Química Biológica, Facultad de Ciencias Exactas y
Naturales, Universidad de Buenos Aires, Argentina and Centro de Investigaciones
sobre Porfirinas y Porfirias (CIPYP), Universidad de Buenos Aires-Consejo
Nacional de Investigaciones Científicas y Tecnológicas, Hospital de Clínicas
José de San Martín, Argentina.
Please see the link here: https://stm.bookpi.org/IST-V6/article/view/6035
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