The purpose of this research is to see how hypothyroidism affects specific haemostatic measures. Thyroid issues, which are more common in women, have been reported to affect the coagulation-fibrinolytic system. The goal of this study is to see if there are any changes in specific haemostatic measures in overt hypothyroid individuals.
With a sample size of 15, hypothyroid individuals and controls were measured
for bleeding time, clotting time, and platelet count. Subjects in the
hypothyroid group had low FT3, FT4, and an increased TSH level (mean 14.9
mU/L). Both groups were similar in age and gender. The findings revealed that
bleeding time and clotting time were both statistically significant, with
p-values of 0.0001 for each parameter. When compared to the control group, the
hypothyroid group had a lower platelet count, which was statistically
significant with a p-value of 0.0001. This discovery was in contrast to
numerous earlier research, which found either an increase in platelet count or
a statistically insignificant decrease in platelet count.
In overt hypothyroid patients, this indicates an elevated bleeding tendency or
hypocoagulable state. The greater the divergence of haemostatic parameters from
normal, the higher the TSH levels. Unraveling the effect of thyroid hormone
changes on haemostatic parameters, as well as the mechanisms involved, may lead
to more treatment choices for altered parameters, reducing the risk of
catastrophic repercussions.
Author(s) Details:
Lanke Vani,
Department of Physiology, Guntur Medical College, Guntur, A.P, India.
Please see the link here: https://stm.bookpi.org/ETDHR-V4/article/view/6054
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