Mean Platelet Volume: An Early Predictor of Diabetic Vascular Complications | Chapter 2 | Advanced Concepts in Medicine and Medical Research Vol. 4

 This affiliate aims to determine mean platelet book (MPV) and platelet count (PC) in diabetics (type2) and non-diabetics and to determine equivalence of MPV and platelet count with abstaining blood sugar. Increased MPV is emerging as an free risk factor for thromboembolism, stroke and heart attack. The majority of Diabetes Mellitus passing are caused by data processing machine- and macro vascular problems of the disease. Larger platelets accompanying larger mean platelet capacity are more prone to thrombosis. Over the course of three months, this anticipated investigation contained 100 participants accompanying type II diabetes and 50 non-diabetic controls. The results showed that diabetics had a meaningful rise in MPV value. The MPV test, that is simple and inexpensive, can be secondhand as a useful tool to monitor subjects for thrombogenicity, particularly in those accompanying altered level of glucose in blood metabolism

Author(s) Details:

Nikita James,
Department of Pathology, Pushpagiri Institute of Medical Sciences and Research Centre, India.

Please see the link here: https://stm.bookpi.org/ACMMR-V4/article/view/12471

Evaluation of Hematological Changes in Donors Post Apheresis: An Institutional Study | Chapter 11 | New Advances in Medicine and Medical Science Vol. 1

 The aim of the study search out evaluate the haematological changes that occured post plateletpheresis in apheresis donor and compare pre and postdonation haematological changes in benefactors and to determine the results of apheresis, plateletpheresis on donor’s health. The output, quality of platelet apheresis group has improved by way of the considerable advancement in the robotic cell separators.This is an practical cross-sectional study exhausted laboratory at RL Jalappa Blood Bank, Tamaka, Kolar, Karnataka, India. The study was done from March 2019 to August 2020. A total of 300 active donors (plateletpheresis backers) were included in the study. All donors seen plateletpheresis (Haemonetics MCS), and pre- and post-donation haematological limits including haemoglobin aggregation, haematocrit (Hct), platelet, white, and red blood cell counts were computed. Postdonation haematological limits such as platelet count, haemoglobin, haematocrit, White Blood Cells (WBC), Red Blood Cells (RBC) counts of the contributor was noted and it was compared accompanying pre-donation haematological limits. Statistical analysis was proficient utilising statistical software SPSS form 16.0. Platelet count, haemoglobin, WBC count, RBC count and haematocrit were noted lower 262 donors and considerably significant reduction was noticed in these parameters postdonation. Donor limit platelet count (lac/mL) value was reduced from 273.57- 224.28 inasmuch as WBC count (cu/mm) predonation value declined from 9.91-8.86 Postdonation, haemoglobin (g/dL) value declined from 14.46-12.91, haematocrit (%) decreased slightly from 45.19- 44.19, RBC count (heap/mm3) decreased from 5.21-5.01. So it is decided that values were dropped off postdonation. Platelets transfusion can be finished either for a remedial or protective cause. Most of the transfusions are given to prevent bleeding in thrombocytopenic subjects.Current research carried out explained SDP is efficacious in of thrombocytopenia healing and it is safe from recipient’s perspective. Technical cadre training, processes carried out under the supervision of transference medicine consultants, and close monitoring of these benefactors are required to prevent unfavorable events for the backers' well-being.

Author(s) Details:

Subhashis Das,
Department of Pathology, Sri Devaraj Urs Academy of Higher Education and Research (SDUAHER), Tamaka, Kolar, Karnataka, India.

Nikhil,
Department of Pathology, Sri Devaraj Urs Academy of Higher Education and Research (SDUAHER), Tamaka, Kolar, Karnataka, India.

Gaurav Khichariya,
Gaurav Khichariya

T. Amrutha,
Department of Pathology, Sri Devaraj Urs Academy of Higher Education and Research (SDUAHER), Tamaka, Kolar, Karnataka, India.

Snigdha Sinha,
Department of Pathology, Sri Devaraj Urs Academy of Higher Education and Research (SDUAHER), Tamaka, Kolar, Karnataka, India.

Please see the link here: https://stm.bookpi.org/NAMMS-V1/article/view/10564

Assessing the Variation of Certain Haemostatic Parameters in Hypothyroidism | Chapter 11 | Emerging Trends in Disease and Health Research Vol.4.

 The purpose of this research is to see how hypothyroidism affects specific haemostatic measures. Thyroid issues, which are more common in women, have been reported to affect the coagulation-fibrinolytic system. The goal of this study is to see if there are any changes in specific haemostatic measures in overt hypothyroid individuals.

With a sample size of 15, hypothyroid individuals and controls were measured for bleeding time, clotting time, and platelet count. Subjects in the hypothyroid group had low FT3, FT4, and an increased TSH level (mean 14.9 mU/L). Both groups were similar in age and gender. The findings revealed that bleeding time and clotting time were both statistically significant, with p-values of 0.0001 for each parameter. When compared to the control group, the hypothyroid group had a lower platelet count, which was statistically significant with a p-value of 0.0001. This discovery was in contrast to numerous earlier research, which found either an increase in platelet count or a statistically insignificant decrease in platelet count.
In overt hypothyroid patients, this indicates an elevated bleeding tendency or hypocoagulable state. The greater the divergence of haemostatic parameters from normal, the higher the TSH levels. Unraveling the effect of thyroid hormone changes on haemostatic parameters, as well as the mechanisms involved, may lead to more treatment choices for altered parameters, reducing the risk of catastrophic repercussions.

Author(s) Details:

Lanke Vani,
Department of Physiology, Guntur Medical College, Guntur, A.P, India.

Please see the link here: https://stm.bookpi.org/ETDHR-V4/article/view/6054