While sevoflurane is becoming more often used in veterinary medicine, it can produce dose-dependent hypotension, hypoventilation, decreased cardiac contractility, and hypothermia. To avoid excessive anaesthetic depth, sevoflurane must be carefully titrated and monitored due to these adverse effects. “Produces immobility in 50% of rats exposed to unpleasant stimulus,” according to one anaesthetic depth evaluation employing a minimum alveolar concentration (MAC). There is currently limited information on the MAC of sevoflurane required for blunting adrenergic responses (MAC-BAR) in cats. As a result, the MAC and MAC-BAR of sevoflurane required to suppress autonomic reactions and intentional movements in cats were compared in this investigation.
Methods: To assess sevoflurane MAC and MACBAR, six adult healthy domestic short haired cats (1 year old, 3 males and 3 females) were anaesthetized with sevoflurane on two occasions with a minimum 14-day washout period.
Results: There was no statistically
significant difference between sevoflurane MAC (2.920.47%) and MAC-BAR
(3.240.41%).
Conclusions and Clinical Implications: These findings suggested that in
sevoflurane-anaesthetized cats, harmful cardiovascular side effects such as
hypotension and decreased cardiac contractility can readily develop.
Author (s) Details
Tadashi Sano
Rakuno
Gakuen University, Japan.
View Book :- https://stm.bookpi.org/RAAVS-V1/article/view/2425
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