The genomes of Helicobacter pylori have a high genetic diversity and rapid microevolution, a characteristic that is thought to have a functional role in the persistence and colonisation of varied human populations. H. pylori isolates can be phylogeographically categorised. We compared MLVA genotypes of 48 H. pylori strains obtained from different locales in southern Russia to characterise diverse strains of this disease in different human populations. When compared to the four publicly accessible genomes, cluster analysis revealed the likely membership of the majority of the strains to the hpEurope population, and two strains to the hpEastAsia population. Every typical PCR laboratory has access to MLVA type, which is a faster and more uniform method for evaluating genetic relatedness. The proposed approach could be useful in molecular epidemiology and possibly for H. pylori population identification. For the first time, a similar study was done in Russia and Europe.
Author (S) Details
Vladimir Mihajlovich Sorokin
Department of Biochemistry, Rostov-on-Don Research Institute for Plague Control, Rostov-on-Don, Russia.
Ruslan Vjacheslavovich Pisanov
Department of Biochemistry, Rostov-on-Don Research Institute for Plague Control, Rostov-on-Don, Russia.
Elena Vadimovna Golubkina
Department of Biochemistry, Astrakhan State Medical University, Ministry of Health of Russia, Astrahan, Russia.
Elena Aleksandrovna Bereznyak
Laboratory of Biological Safety and Highly Dangerous Infections Treatment, Rostov-on-Don Research Anti-Plague Institute, Russia.
Lubov Aleksandrovna Prozorova
Department of Biochemistry, Rostov-on-Don Research Institute for Plague Control, Rostov-on-Don, Russia.
View Book :- https://stm.bookpi.org/RPMB-V7/article/view/2576
No comments:
Post a Comment