Background: The purpose of this study was
to see if Resveratrol might help protect female Sprague Dawley rats from
developing breast cancer caused by 7,12 Dimethylbenzanthracene (DMBA), as well
as if it could help downregulate COX 2, an enzyme seen in breast cancer
tissues. Methods: In this investigation, 40 female Sprague Dawley rats (n = 10
per group) were employed. 6 week old rats were divided into four groups: group
1 received pulverised rodent diet, group 2 received DMBA and diet, group 3
received DMBA and diet with Resveratrol 100mcg, and group 4 received DMBA and
diet with Resveratrol 100mcg. 200mcg. After 120 days, the study was terminated,
and tumours were assessed for multiplicity, incidence, and histology. Cox 2
expression was examined by Western blot analysis. One way variance and Tukey's
comparison test were used to test the values statistically. Body weight and
tumour volume were similar in the resveratrol-treated groups, and there was a
very lengthy latency time for tumour initiation, as well as a reduction in
tumour multiplicity and incidence. Group 2 had a tumour incidence of
42.2710.17, Group 3 had a tumour incidence of 21.915.87, and Group 4 had a
tumour incidence of 13.733.98. Group 2 had a tumour multiplicity of 0.89090.30,
group 3 had a tumour multiplicity of 0.10360.04, and group 4 had a tumour
multiplicity of 0.045450.02. In groups 2, 3, and 4, histopathological
investigation indicated ductal carcinoma, mild tissue necrosis, and
fibroadenoma. Resveratrol reduces COX 2 expression in breast carcinoma and has
a chemopreventive impact against DMBA-induced breast cancer, according to the
findings.
Author(s) Details
Dr. Aneena Suresh
Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of
Higher Education & Research, Ooty, Nilgiris, India.
Rajat Rana
Department of Pharmacy Practice, Asmara College of Health Sciences, Asmara,
Eritrea.
Keerthana C.
Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher
Education & Research, Ooty, Nilgiris, Tamil Nadu, India.
View Book :- https://stm.bookpi.org/TIPR-V9/article/view/2528
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