Background: PPI is used in between 45 and
85 percent of instances in India. In 82.96 percent of cases, patients with
chronic renal illness were prescribed a PPI. Recent case reports, however,
suggest that PPI can cause AIN. Because many patients take many drugs, it's
tough to estimate the exact rate of this uncommon side effect, making
establishing a causal relationship between AIN and PPI much more challenging.
Early detection of AIN and withdrawal of the offending medicine may delay the
progression of AIN to end-stage chronic renal disease. As a result, we decided
to conduct research to see if there is a link between PPI and AIN. The goal of
the study was to see what effect concomitant usage of PPI and NSAID or AMA had
on the histopathology of experimental animals. The goal was to use
histopathological investigations to determine the effect of simultaneous
treatment of PPI with NSAIDS/antimicrobials on kidneys and compare it to a
normal histological picture to see what changes had occurred due to medication
administration. The rats used in the experiment weighed between 150 and 250
grammes. Omeprazole, Three groups were given pantoprazole, rabeprazole, and
diclofenac for 28 days: group A received nothing, group B received diclofenac,
and group C received ofloxacin. The animals with disturbed RFTs were grouped
together after the 28th day. Two animals were sacrificed for each group. Their
histopathology tests were also finished. The RFTs of at least three rats in
each group were found to be aberrant. And, whether or not AIN is used, the
majority of histopathological studies show structural and vascular changes.
Conclusions: PPIs alone are known to cause AIN, but when other nephrotoxic
medications are taken, the risk of AIN increases.
Author(s) Details
Dr. Ramachandra Prabhakar Limay
Department of Pharmacology, Bharati Vidyapeeth (Deemed to University), Medical
College and Hospital, Sangli, Maharashtra, India.
Dr. Shabbir Rafik Pendhari
Department of Pharmacology, Bharati Vidyapeeth (Deemed to University), Medical
College and Hospital, Sangli, Maharashtra, India.
Hanul Medizin Pvt Ltd, Pune, Maharashtra, India.
View Book :- https://stm.bookpi.org/TIPR-V9/article/view/2527
No comments:
Post a Comment