A small percentage of hyperthyroid patients are resistant to antithyroid medicines. Cholestyramine has been shown in multiple studies to sequester thyroid hormones in the intestine, resulting in a faster drop in thyroid hormone levels when administered as an adjuvant treatment to traditional antithyroid medications. The goal of this study is to provide a case of resistant Graves' illness that responds well to adjunctive oral cholestyramine, as well as to explore the safety and efficacy of this medicine. We present the case of a 27-year-old female patient with Graves' disease who had been experiencing thyrotoxicosis symptoms for 18 months and had not reacted to even a high dose of Neomercazol, Propranolol, and Prednisolone. Her T4 level was 19.3 (4.9–11.0 g/mL) at the time of presentation. As an additional therapy, we give oral cholestyramine (5g twice day). After one week, the patient's T4 level was 10.6 (4.9–11.0 g/mL), indicating a significant response. After another week of the same medication, a total thyroidectomy was performed. The postoperative period was uneventful and free of problems.
Author (s) Details
Sadq Ghaleb Kadem
Department of Surgery, Al-Shiffa General Hospital, Basrah, Iraq.
Zainab Taher Ibrahim
Department of Radiology, Al-Sadder teaching Hospital, Basrah, Iraq.
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