Study on Mifepristone for Cervical Ripening and Induction of Labor in Previous LSCS Cases-Experience from a Single Centre of North India | Chapter 10 | Highlights on Medicine and Medical Science Vol. 14

 Inducing labour in a previous caesarean operation presents a significant challenge for the doctor (CS). Induction of labour rates in women with past CS are falling globally. The tendency is toward elective recurrent caesarean procedures if a pregnancy must be ended for obstetric reasons. Vaginal birth had fewer difficulties than repeat CS, especially in a community like ours where multiparity is more common. As a result, there is a desire for an agent that has a superior vaginal birth outcome.

The study's goal was to see if Mifepristone could help with cervical softening and induction of labour in previous caesarean instances. It also had the goal of determining the induction delivery interval as well as mother and foetal outcomes.

Methods: This was a prospective research on fifty-two term pregnant females with one previous caesarean section referred for labour induction for various reasons in a tertiary care centre in North India. They were placed into two research groups of twenty-six people each at random. Females in Group A were given Mifepristone tablets, whereas females in Group B were given a placebo.

Age, gestational time, and Bishop score at induction were not different between the two groups. In both groups, the most prevalent reason for induction was a post-dated pregnancy. There was a statistically significant difference in induction to onset of labour with Mifepristone when compared to the control group. The time between induction and the commencement of labour in the mifepristone and control groups was 24 hours 7 minutes and 37 hours 3 minutes, respectively. The mean induction delivery interval in the cases and control groups was 33 hours and 1 minute and 46 hours and 9 minutes, respectively, however this was not statistically significant. In the mifepristone group, 21 patients (80.7%) delivered vaginally, compared to 15 patients (57.6%) in the control group.

Conclusions: This study found that Mifepristone is a simple and effective approach for IOL in term women who have had previous LSCS, with a favourable outcome, and that its usage offers an intriguing new alternative to traditional uterotonic drugs when induction is required in past LSCS patients.

Author (S) Details

Gagan Lata
Department of Obstetrics and Gynecology, Adesh Medical College & Hospital, Mohri, Shahbad, Haryana, India.

Sukhbir Pal Kaur
Department of Obstetrics and Gynecology, Adesh Medical College & Hospital, Mohri, Shahbad, Haryana, India.

Susmita Sharma
Department of Obstetrics and Gynecology, Adesh Medical College & Hospital, Mohri, Shahbad, Haryana, India.

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