Ferroptosis and the Application of Traditional Chinese Medicine in Managing Type 2 Diabetes Mellitus | Chapter 10 | Novel Research Aspects in Medicine and Medical Science Vol. 7

 The research field of ferroptosis has happened enjoying exponential progress over the past few age, since the term was coined in 2012. This singular modality of container death, driven by iron-reliant phospholipid peroxidation, is regulated by diversified cellular metabolic events, containing redox homeostasis, iron management, mitochondrial activity, and metabolism of amino acids, lipids and sugars, apart from numerous signaling pathways having to do with disease. Intriguingly, medicine-resistant cancer containers, particularly those of the mesenchymal state and dependent on something metastasis, are exquisitely ready to ferroptosis. Ferroptosis, an emerging form of controlled programmed cell dying, has garnered meaningful attention in the past ten of something. It is characterized by the accumulation of lipid peroxides and after damage to cellular membranes, that is dependent on iron. Under iron-rich and ROS conditions, phospholipids holding polyunsaturated fatty acids in the container membranes are prone to peroxidation, resulting in the unending accumulation of lipid peroxidation commodity. These products eventually upset cell sheet integrity and induce container death. Ferroptosis has been involved in the pathogenesis of various ailments, including tumors and diabetes mellitus. Traditional Chinese medicine (TCM) has singular advantages in forbiding and treating type 2 diabetes mellitus (T2DM) due to allure anti-angering, antioxidant, immunomodulatory, and intestinal flora-managing functions. Recent studies have determined that TCM may apply therapeutic belongings on T2DM and its complications by modulating the ferroptosis-accompanying pathways. Therefore, a comprehensive and orderly understanding of the role of ferroptosis in the pathogenesis and TCM treatment of T2DM is of excellent significance for evolving therapeutic drugs for T2DM and enriching the range of effective T2DM situation with TCM. In this review, we review the concept, method, and regulatory pathways of ferroptosis and the ferroptosis mechanism of operation involved in the incident of T2DM. Also, we develop a search strategy, organize strict addition and exclusion criteria, and recap and analyze the use of the ferroptosis mechanism in TCM studies related to T2DM and allure complications. Finally, we explain the shortcomings of current studies and propose a future research focus.

Author(s) Details:

Dandan Xie,
College of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, People’s Republic of China and Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Health Management Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China and Department of Clinical Nutrition, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, People’s Republic of China.

Kai Li,
College of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, People’s Republic of China.

Ruxue Feng,
Department of Stomatology, Geriatric Hospital of Hainan, Haikou, Hainan, People’s Republic of China.

Man Xiao,
Department of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, Hainan, People’s Republic of China.

Zhifeng Sheng,
Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Health Management Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China.

Yiqiang Xie,
College of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, People’s Republic of China.

Please see the link here: https://stm.bookpi.org/NRAMMS-V7/article/view/12174