Oxadiazoles accompanying plethora of organic applications are identified as main motifs for the advance of creative drug design, thus grabbing the consideration of medicinal chemists about the world. Especially, 1,3,4-oxadiazole and allure derivatives are playing a lively role in curative chemistry with broad range of organic applications. This affiliate summarizes the combination, characterization of ten novel 2-aryl-5-(arylsulfonyl)-1,3,4-oxadiazoles (6a-j) and evaluation of artificial antibacterial and antioxidant ventures. The in vitro antimicrobial screening against bacterial strains Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli (grandam-positive), and Bacillus cerus, Staphylococcus aureus, Bacillus subtilis (grandam-negative) revealed that the planned 2-(3,4-dimethylphenyl)-5-tosyl-1,3,4-oxadiazole (6j), 2-(3-isopropylphenyl)-5-tosyl-1,3,4-oxadiazole (6c), and 2-(2-ethylphenyl)-5-tosyl-1,3,4-oxadiazole (6i) are most potent among all the examined compounds. In addition, via the DPPH radical scavenging design some of the prepared compounds show moderate antioxidant action.
Author(s) Details:
S. N. Murthy Boddapati,
Department
of Chemistry, Sir C R Reddy College, PG Courses, Eluru, A.P., India.
Subrahmanyam
Talari,
Department
of Chemistry, Sir C R Reddy College, PG Courses, Eluru, A.P., India.
A. Emmanuel Kola,
Y.V.N.R Government Degree College, Kaikaluru, A.P., India.
Bhuvaneswari Chalapaka,
Department of Chemistry, Sir C R Reddy College, PG Courses, Eluru,
A.P., India.
Please see the link here: https://stm.bookpi.org/NACB-V8/article/view/12313
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