Cervical Lesions Associated with Human Papillomavirus Infection after Post-Vaccination: An Observational, Descriptive Study | Chapter 2 | Advanced Concepts in Medicine and Medical Research Vol. 2

 This stage aims to examine the development of lesions caused by HPV contamination in patients after immunization in various occasion periods, taking into account the age 2002 to 2006 (prior to the cure's introduction in Spain), 2009 to 2011 (current introduction of the vaccination), and 2020 to 2021 (age when the vaccine was widely acknowledged) at a specific emergency room. Human papillomavirus (HPV) is the most superior sexually transmitted bug globally. Persistent extreme-risk HPV infection can result in cervical precancerous lesions and cervical tumor, with 70% of cervical tumor cases associated with extreme-risk types HPV16 and 18. HPV infection imposes a meaningful financial and intellectual burden. This is an observational, descriptive, backward-looking research based on the judgment of the results of the biopsies of patients lesions had connection with HPV infection at a big tertiary emergency room, Hospital Clínico San Carlos, in Madrid, Spain. The data were taken from three various time periods: 2002-2006, 2009-2011, 2020-2021 in consideration of understand the potential alternatives in these lesions after cure introduction. The dossier of 946 women were examined. During these three periods, skilled was noted a curtailing trend in the rate of squamous container carcinoma, a strength in the rate of adenocarcinoma remains, and an growing rate of cervical intraepithelial neoplasia grades 2 - 3 (CIN 2-3) lesions. Another remarkable change organized was the mean ages of the patients with these lesions, as these had raised in the three lesions caused by HPV following in position or time the instauration of the cure. Our investigation discloses that the recognition of added high risk serotypes, different from simple 16 and 18, as well as those accompanying indeterminate risk, has sustained a progressive increase (from 24.24% and 14.11% individually in 2002-2006 to 40.42% and 28.34% in 2020-2021). The effectiveness of the vaccines grown so far, against the HPV serotypes they contain has happened proved in our case. The data shows that the occurrence of squamous cell malignant growth in the uterine cervix has curtailed in our community. Parallel to this remark, a raise in the mean age of disease for both squamous cell abnormal growth in animate being and its CIN 2-3 forerunner lesions have been settled, as has a shift in the infective current of HPV serotypes not covered in current vaccines.

Author(s) Details:

Montserrat de la Torre Serrano,
Instituto de Investigación Sanitaria, Hospital Clínico San Carlos, Spain and Hospital Clínico San Carlos Madrid, Spain.

Ana María Colino Gallardo,
Instituto de Investigación Sanitaria, Hospital Clínico San Carlos, Spain and Hospital Clínico San Carlos Madrid, Spain.

M. Jesús Fernández Aceñero,
Instituto de Investigación Sanitaria, Hospital Clínico San Carlos, Spain and Hospital Clínico San Carlos Madrid, Spain.

Please see the link here: https://stm.bookpi.org/ACMMR-V2/article/view/12263