Vascular Calcification, Insight in Its Pathophysiological Pathways, Genetics and Clinical Aspects | Chapter 6 | Advanced Concepts in Medicine and Medical Research Vol. 1

 The pathophysiology and historical regulation of this process are two together evaluated in this place chapter along with the key devices at play. Vascular calcification is highly guide cardiovascular disease death, particularly in high risk cases with diabetes and never-ending kidney diseases (CKD). In ancestry vessels, intimal calcification is guide atherosclerosis, whereas median calcification is a non-occlusive process which leads to raised vascular stiffness and reduced vascular agreement. In the valves, calcification of the leaflets can change the machinelike properties of the tissue and influence stenosis. For many decades, vascular hardening has been noted by way of of aging. Recent research suggests that arterial hardening is an independent cardiovascular risk determinant (CRF) for morbidity and mortality. New studies have specified the existence of complex physiopathological mechanisms that flocks redness, oxidation, the release of synthetic mediators, and genetic factors that advance the osteochondrogenic differentiation of vascular smooth influence cells (VSMC).

Author(s) Details:

Luis Fernando Escobar Guzman,
Department of Cardiology/Emergency, BP- A Beneficência Portuguesa de São Paulo, Department of Cardiology, Cruz Azul Hospital, São Paulo, Brazil.

Cristian Andrés Escobar Guzman,
Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.

José Ramon Lanz-Luces,
BP- A Beneficência Portuguesa de São Paulo, São Paulo, Brazil.

Michele de Lima,
Nove de Julho University, São Paulo, Brazil.

Please see the link here: https://stm.bookpi.org/ACMMR-V1/article/view/12293