Based on Association Rules of the System Construction of Chinese Medicine Prescription Data Mining and Mining Research on the Spleen and Heat Type of Prescription | Chapter 5 | Diagnostic and Treatment Advances in COVID-19 and SARS-CoV-2

 China medicine has a long history, Chinese traditional medicine (TCM) is an important component of Chinese medicine, but also reflect the basic means of TCM curative effects. Compounds of TCM are mixture of drugs according to certain compatibility rules, complex composition. In clinical application certain herbs are selected following the compatibility law as a means, to achieve treatment for different diseases. Therefore, the effective components of Chinese medicine, the effective components of single drug or effective ingredients of the traditional Chinese medicine prescription are not compatibility, studying the superposition, inhibition the interaction between the components is essential. In recent years, the application of modern information technology has been developed, and applied in a lot of the research of TCM. Especially the technology of data mining, excavation of the Chinese native medicine compound prescription has become an important means of modernization of traditional Chinese medicine. Data mining technology is a set of scientific method to solve the problem of a large number of data from the application of various fields and put forward, mainly in order to discover the hidden knowledge and rules in the data, provide data and theoretical support for the decision scheme of human. Many TCM databases have been established. So we attempt to study the application of data mining technology in traditional Chinese medicine effective constituents in compound prescription and regulation, try to analyze and explore the effectiveness of compositions of TCM by computer. This paper uses the data mining technology as a means, analysis of composition rules and active components on the spleen and stomach and heat compound prescriptions, which mainly includes the following work: Data mining is the core algorithm. Some set of frequent items mining method based on APriori method, candidate set generation needs to constantly scanning the database, time consumption. FP-growth is a kind of mining method without generating candidate itemsets important frequent item sets.In this paper, based on the improved algorithm, the new algorithm uses the modified FP-tree and the head table structure, produce only FP-tree once, and produced only head table structure at each recursion. The new algorithm can obtain the same as the original algorithm of frequent item sets mining results, but the speed of at least twice faster than the FP-growth. Screening of the data, the other agent data preprocessing, create the database, use the improved algorithm, the initial establishment of effective component and computer composing principle of traditional Chinese medicine compound simulation system, the system through the data mining techniques: frequent item sets, association rules, clustering analysis algorithm, carries on the analysis to the frequency of drug ingredients, compound symptom frequency, medicine sickness connection, pharmaceutical composition clustering, find out the related effective ingredients and disorder of spleen and stomach and Qingre prescription among.

Author(s) Details:

Xiyuan Zhang,
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.

Jianshe Yang,
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China, Tongji University School of Medicine, Shanghai 200072, China and Gansu Medical College, Pingliang 744000, China.

Please see the link here: https://stm.bookpi.org/DTACSC/article/view/9555

Study on Urinary Metabolomics of Premenstrual Dysphoric Disorder Patients with Liver-qi Depression Syndrome Treated with Xiaoyaosan Study Protocol Clinical Trial (SPIRIT Compliant) | Chapter 14 | Insights into the Prevention and Treatment of Depression with Famous TCM Prescription Xiaoyaosan

 Introduction: Premenstrual dysphoric disorder (PMDD) is a serious form of premenstrual syndrome with mental symptoms as its main manifestation, which seriously affects women's health and daily life. Some basic research and clinical studies have shown that the Chinese herbal medicine of Xiaoyaosan can relieve the symptoms of mental disorders with few side effects. The aim of this study is to evaluate the clinical efficacy of Xiaoyaosan for treating PMDD with liver-qi depression syndrome. In addition, metabonomics and small molecular marker compounds closely related to the pathogenesis of PMDD are expected to be found, and mechanism of Xiaoyaosan is further explored from the metabolic level.

Methods and Analysis: This study is a clinical pilot trial. Thirty PMDD patients with liver-qi depression syndrome and thirty healthy participants will be recruited. Study participants will be assigned in a 1:1 ratio to 2 groups: a normal control group and Xiaoyaosan treatment group. The treatment group will receive the Chinese patent medicine of Xiaoyaosan for 3 menstrual cycles. The primary outcome is the syndrome change in the Daily Record of Severity of Problems (DRSP). The secondary outcome is improvement in TCM syndrome, which will be measured with TCM symptom score scale. Urine metabolism profiles of participants by liquid chromatograph-mass spectrometer (LC-MS) method will be measured to explore the mechanism of PMDD pathogenesis and action of Xiaoyaosan on PMDD.

Discussion: This trial will evaluate the effectiveness and the therapeutic mechanism from the metabolomics level of Xiaoyaosan in individuals with PMDD. If successful, the outcome of this trial will provide a viable treatment option for PMDD patients and objective evidence on the efficacy of Xiaoyaosan for PMDD.

Ethics and Dissemination: The trial has been approved by the Institutional Ethics Committee of Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (file number: DZMEC-KY-2019-73). Written informed consent will be obtained from all participants. The results of the study will be published in peer-reviewed journals or communicated via yearly reports to funding bodies.

Trial registration: Chinese Clinical Trial Registry, ChiCTR1900026296.

Author(s) Details:

Mengbai Xu,
School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing-100029, China and Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.

Yanfeng Liu,
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.

Yu Guo,
School of Traditional Chinese Medicine, Jinan University, Guangzhou, China.

Chenyue Liu,
School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing-100029, China.

Yueyun Liu,
School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing-100029, China.

Zhiyi Yan,
School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing-100029, China.

Yajing Hou,
School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing-100029, China.

Xiaojuan Li,
School of Traditional Chinese Medicine, Jinan University, Guangzhou, China.

Qingyu Ma,
School of Traditional Chinese Medicine, Jinan University, Guangzhou, China.
 
Xuan Zhou,
School of Traditional Chinese Medicine, Jinan University, Guangzhou, China.
 
Liuqing Liu,
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
 
Sheng Huang,
Jiuzhitang Co., Ltd., Changsha, China.
 
Jiaxu Chen,
School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing-100029, China and Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou-510632, Guangdong, China.

Please see the link here: https://stm.bookpi.org/IPTDFTPX/article/view/11277

Influence of Xiaoyaosan on Depressive-like Behaviors in Chronic Stress-depressed Rats through Regulating Tryptophan Metabolism in Hippocampus | Chapter 5 | Insights into the Prevention and Treatment of Depression with Famous TCM Prescription Xiaoyaosan

 Background: Tryptophan metabolism has always been considered to play a vital role in mental disorder diseases, and how traditional Chinese formula Xiaoyaosan regulates the tryptophan metabolism is a complement to the pathogenesis of depression. This study established a depression rat model by the chronic immobilization stress (CIS) method and observed the change in tryptophan metabolism in hippocampus and the effects of Xiaoyaosan.

Methods: Forty-eight male Sprague Dawley (SD) rats were randomly divided into the following four groups: control group, CIS group, Xiaoyaosan group, and fluoxetine group. The depression model was established by the 21-day CIS. The food intake and body weight were recorded, and the sucrose preference test (SPT), novelty suppressed feeding (NSF) test and open field test (OFT) were also used to evaluate the model. Then, the contents of tryptophan and 5-hydroxytryptamine (5-HT) in hippocampus were detected by the ELISA method, and the expression levels of tryptophan hydrogenase 2 (TPH2) and indoleamine 2,3-dioxygenase 1 (IDO1) in hippocampus were determined by quantitative reverse transcriptase polymerase chain reaction reaction (qRT-PCR) and Western blot methods.

Results: The behavioral data showed a significant difference between the model group and the normal group. The 5-HT content in the hippocampi of CIS rats was significantly reduced, whereas the tryptophan content in the hippocampi of model rats was significantly increased. The TPH2 level in hippocampus of the model group was significantly decreased, and the IDO1 level was significantly increased. Xiaoyaosan and fluoxetine could significantly reverse these changes and had obvious curative effects.

Conclusion: The abnormal tryptophan metabolism existed in the hippocampi of chronic stress-depressed rats, which was closely related to the pathogenesis of depression. Xiaoyaosan could improve the tryptophan metabolism by regulating the expression levels of TPH2 and IDO1, thus exerting an antidepressant-like effect.

Author(s) Details:

Haiyan Jiao,
Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou-510632, Guangdong, China.

Zhiyi Yan,
Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou-510632, Guangdong, China.

Qingyu Ma,
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing-100029, China.

Xiaojuan Li,
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing-100029, China.

Youming Jiang,
Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou-510632, Guangdong, China.

Yueyun Liu,
Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou-510632, Guangdong, China.

Jiaxu Chen,
Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou-510632, Guangdong, China and School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11 North Third Ring Road Chaoyang District, Beijing-100029, China.

Please see the link here: https://stm.bookpi.org/IPTDFTPX/article/view/11266

Practical Applications of Laser Acupuncture | Chapter 3 | Advanced Concepts in Medicine and Medical Research Vol. 2

 Objective: Laser acupuncture is a non-obtrusive modality that involves the use of depressed-intensity, nonthermal laser beam of traditional acupuncture sites to extort stimulation. We aimed to scrutinize the practical applications of ray of light acupuncture.Methods: A narrative review of literature and case presentations was administered.Results: Although the precise means of action remains ambiguous, the therapeutic applicability of ray of light acupuncture is broad. The empirical data idea the effectiveness of laser acupuncture in the situation of several healing disorders, including obesity, diabetes mellitus, musculoskeletal and combinational tissue diseases, ischemic stroke, vascular senility, postherpetic neuralgia, acute kidney harm after infection of blood, myopia, amblyopia, dry eye, acute lymphoblastic leukemia, never-ending kidney disease, atopic rash, opioid use disorders, autism spectrum disorder, sudden sensorineural trial loss and tinnitus, emergent short stature, and pediatric dysphagia. To date, no studies have reported the reactions or complications associated with ray of light acupuncture.Conclusions: Laser acupuncture has been recognized as a conceivably valuable alternative therapeutic modality in modern medical practice when executed by competent medical experts. Additional investigation is required to exactly establish ideal treatment limits, including determinants such as wavelength, portion of drug or other consumable, and intensity, with the aim of optimizing the physical advantages and cost-effectiveness of ray of light acupuncture therapy.

Author(s) Details:

Wen-Long Hu,
Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan and Kaohsiung Medical University, College of Medicine, Kaohsiung, Taiwan and Fooyin University College of Nursing, Kaohsiung, Taiwan.

Chun-En Kuo,
Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan and School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan.

Szu-Ying Wu,
Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan and School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan.

Yi-Hsun Tsai,
Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Han-Ching Wang,
Han-Ching Wang Pediatric Clinic, Kaohsiung, Taiwan.

Yu-Chiang Hung,
Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Chia-Hui Lin,
Department of Acupuncture, China Medical University Hospital, Taichung, Taiwan.

Mao-Feng Sun,
College of Chinese Medicine, China Medical University, Taichung, Taiwan.

Please see the link here: https://stm.bookpi.org/ACMMR-V2/article/view/12264

Ferroptosis and the Application of Traditional Chinese Medicine in Managing Type 2 Diabetes Mellitus | Chapter 10 | Novel Research Aspects in Medicine and Medical Science Vol. 7

 The research field of ferroptosis has happened enjoying exponential progress over the past few age, since the term was coined in 2012. This singular modality of container death, driven by iron-reliant phospholipid peroxidation, is regulated by diversified cellular metabolic events, containing redox homeostasis, iron management, mitochondrial activity, and metabolism of amino acids, lipids and sugars, apart from numerous signaling pathways having to do with disease. Intriguingly, medicine-resistant cancer containers, particularly those of the mesenchymal state and dependent on something metastasis, are exquisitely ready to ferroptosis. Ferroptosis, an emerging form of controlled programmed cell dying, has garnered meaningful attention in the past ten of something. It is characterized by the accumulation of lipid peroxides and after damage to cellular membranes, that is dependent on iron. Under iron-rich and ROS conditions, phospholipids holding polyunsaturated fatty acids in the container membranes are prone to peroxidation, resulting in the unending accumulation of lipid peroxidation commodity. These products eventually upset cell sheet integrity and induce container death. Ferroptosis has been involved in the pathogenesis of various ailments, including tumors and diabetes mellitus. Traditional Chinese medicine (TCM) has singular advantages in forbiding and treating type 2 diabetes mellitus (T2DM) due to allure anti-angering, antioxidant, immunomodulatory, and intestinal flora-managing functions. Recent studies have determined that TCM may apply therapeutic belongings on T2DM and its complications by modulating the ferroptosis-accompanying pathways. Therefore, a comprehensive and orderly understanding of the role of ferroptosis in the pathogenesis and TCM treatment of T2DM is of excellent significance for evolving therapeutic drugs for T2DM and enriching the range of effective T2DM situation with TCM. In this review, we review the concept, method, and regulatory pathways of ferroptosis and the ferroptosis mechanism of operation involved in the incident of T2DM. Also, we develop a search strategy, organize strict addition and exclusion criteria, and recap and analyze the use of the ferroptosis mechanism in TCM studies related to T2DM and allure complications. Finally, we explain the shortcomings of current studies and propose a future research focus.

Author(s) Details:

Dandan Xie,
College of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, People’s Republic of China and Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Health Management Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China and Department of Clinical Nutrition, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, People’s Republic of China.

Kai Li,
College of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, People’s Republic of China.

Ruxue Feng,
Department of Stomatology, Geriatric Hospital of Hainan, Haikou, Hainan, People’s Republic of China.

Man Xiao,
Department of Biochemistry and Molecular Biology, Hainan Medical University, Haikou, Hainan, People’s Republic of China.

Zhifeng Sheng,
Hunan Provincial Key Laboratory of Metabolic Bone Diseases, Department of Metabolism and Endocrinology, National Clinical Research Center for Metabolic Diseases, Health Management Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China.

Yiqiang Xie,
College of Traditional Chinese Medicine, Hainan Medical University, Haikou, Hainan, People’s Republic of China.

Please see the link here: https://stm.bookpi.org/NRAMMS-V7/article/view/12174

Traditional Chinese Medicine Techniques Impact on the Quality of Life of the Older People | Chapter 12 | Current Progress in Medicine and Medical Research Vol. 7

 The focus concerning this study was to decide the potential influence of traditional Chinese cure (TCM) practices on the quality of existence (QOL) of the elderly. Elders endure be interviewed as journalists on the value of their own lives. Two non-selected sign up groups of Rio de Janeiro (Brazil) municipality tenants were studied: a control group (36 earlier adults) the one did empty TCM and a group participating in an experiment (28 earlier people) that acted use TCM at the ABACO/Sohaku-in Institute in Brazil. The WHOQOL-Old questionnaire, grown by the World Health Organization, was working, as were descriptive mathematical approaches to a degree mean and standard deviation. The Shapiro-Wilk test was used to guarantee that the distribution was usual. Furthermore, for the intergroup comparison, the Student t test was used to facets 2, 4, 5, 6, and total score, and the Mann-Whitney U rank test was applied to surfaces 1 and 3, both tests engaged to examine the P profit difference middle from two points experimental and control groups. The standard of significance secondhand was 95% (P >0.05). The experimental group had defeater in competition overall and individual QOL scores. It was persistent that TCM might boost the QOL of the elderly. The overall end of this study, that reports a greater QOL for the traditional who sustain TCM treatment, is advantageous for the adoption of TCM processes in the West, at least with the senior population.

Author(s) Details:

Helena Andrade Figueira,
Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Olivia Andrade Figueira,
Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Joana Andrade Figueira,
Pontifícia Universidade Católica do Paraná, Brazil.

Alan Andrade Figueira,
Pontifícia Universidade Católica do Paraná, Brazil.

Estelio Henrique Martin Dantas,
Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Delson Lustosa Figueiredo,
Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Ronaldo Vivone Varejão,
Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Adonay Pimentel Aleluia Freitas Júnior,
Universidade Evangélica de Goiás, Brazil.

 

Jymmys Lopes dos Santos,
Federal University of Sergipe, Brazil.
 
Cilene Oliveira Feu Galiasso,
Universidade Estadual de Roraima, Brazil.
 
Carlos Antônio Feu Galiasso,
Universidade Estadual de Roraima, Brazil.
 
João Victor da Costa Alecrim,
Universidade Estadual de Roraima, Brazil.

Please see the link here: https://stm.bookpi.org/CPMMR-V7/article/view/11637

Akabane Test, Theory and Practice of Thermopuncture Diagnostics and Correction | Book Publisher International

The book is based on findings from analysing thousands of patients using the Akabane test over the course of 30 years of using these tools. These information is easily processed mathematically and is supported by evidence from evidence-based medicine research. Recently, there has been a global rise in interest in what are referred to as "unconventional methods of diagnosis and therapy." The information will enable us to reevaluate this prevalent illness and identify fresh new approaches for its early detection, monitoring, and treatment.

 

Author (s) Details

Muzhikov Valery Gennadievich

CEO 'Med Byte LLC', St. Petersburg, Russia.

 

Please see the link here:-  https://stm.bookpi.org/ATTPTDC/issue/view/750

 

New Discovery of the Effect of Acupoints on the Human Body | Chapter 7 | New Frontiers in Medicine and Medical Research Vol. 6

Modern medicine tells us that the human body is made up of organs like the heart, lungs, liver, kidneys, spleen, stomach, brain, nerves, muscles, bones, blood vessels, and blood, but Traditional Chinese Medicine believes that the human body has another structure called Jing Luo and Shu Xue that exists alongside these tissues and organs. Jing Luo translates to Meridians and Collaterals, which refers to the longitudinal line of the human body and the net that surrounds it. Because acupuncture stimulates Shu Xue's position, Shu Xue signifies holes dispersed on Jing Luo and outside Jing Luo. Shu Xue is translated into an English acupuncture point, abbreviated as acupoint or point, since massage and other methods can treat ailments. In Traditional Chinese Medicine, meridians and acupoints are particular understanding of the human body structure. For thousands of years, Traditional Chinese Medicine has not only drawn the distribution map of the meridians and acupoints in the human body, but has also used them to treat ailments. There are hundreds of these acupoints, and stimulating each one with acupuncture, massage, or other treatments has a unique effect on the human body, and can be used to cure a variety of ailments. But, in order to treat various ailments, what effect does stimulating each acupoint have on the human body? Traditional Chinese Medicine is a hazy and unintelligible topic that cannot be proven by experiments.

This document presents a clear and accurate exposition of the effects on the human body and ailments that can be treated with acupoint massage, based on the author's more than 30-year research. These assertions can be verified through experiments, hence they are seen to be trustworthy. After the contents of this paper are proven by others through experiments, it is hoped that meridians, acupoints, and massage therapy can be included into contemporary medicine and become a component of modern medicine in the future.

Not only does massaging acupoints treat many disorders that are difficult to treat with drugs, but it also has simple methods and is inexpensive.

Author (S) Details

Li Xiaoguang
Traditional Chinese Medicine, Shaanxi Province, China.

View Book :- https://stm.bookpi.org/NFMMR-V6/article/view/2765