A Breif Overview on Alzheimer’s Disease: Potential Targets | Chapter 7 | Current Innovations in Disease and Health Research Vol. 2

 The aim concerning this article search out survey the potential targets of Alzheimer’s Disease (AD) as it is prompted through many pathways. The most common cause of senility is Alzheimers disease. Averagly, 6.2 millions Americans old 65 and earlier are living with Alzheimers type of senility today. This number commit increase to 13.8 heap by 2060. FDA has approved few drugs like Donepezil, Galantamine, Rivastigmine and Memantine for AD. These drugs primarily act on two goals like Acetylcholinesterase enzyme (Drugs like like Donepezil, Galantamine, Rivastigmine and NMDA receptors (Drug like Memantine). But many potential marks are complicated in AD. Acetylcholinesterase and tau proteins are widely investigated in the intellect tissues in this ailment, but many factors concede possibility provoke the pathogenesis of this ailment. The anomalous prepare of APP by β-secretases and γ -secretases leads to result of A β ₄₀ and A β42 monomers, which further oligomerize and aggregate into doddering plaques  that leads to impairement in neuronal transmission. Generally goals like acetylcholinesterase, Amyloid plaques and Tau proteins are known to cause Alzheimers Disease. But skilled are differing mechanisms like Neurotransmitters connection (GABA, Histaminergic and NMDA), Caspases, beta arrestins, Involvement of ACE, NO are more complicated in the pathogenesis of Alzheimers disease. Some of the gene mutations like APOE, Presenilin (PSEN 1),  Presenilin 2 (PSEN 2) further paves the way for Alzheimers disease. The present study was projected to explore the miscellaneous uncharted targets of Alzheimers disease.

Author(s) Details:

Kondumahanti V. N. Lakshmi,
Nirmala College of Pharmacy, Acharya Nagarjuna University, Atmakur- 522503, Andhra Pradesh, India.

S. K. Abdul Rahaman,
Nirmala College of Pharmacy, Acharya Nagarjuna University, Atmakur- 522503, Andhra Pradesh, India.

G. Sai Sri Lakshmi,
Nirmala College of Pharmacy, Acharya Nagarjuna University, Atmakur- 522503, Andhra Pradesh, India

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