Synthesis and Characterization of Some Biologically Active Fluorinated Heterocycles Like Benzothiazepines & Pyrazolines | Chapter 5 | Current Topics on Chemistry and Biochemistry Vol. 9

 Fluorinated heterocycles like benzothiazepines & Pyrazolines shows apparent biological activities. 4-Bromo-2-fluorobenzaldehyde 1 when medicated with substituted hydroxy acetophenones 2 yields chalcones 3. These chalcones were refluxed accompanying 2-aminothiophenol gave “2-[2-(4-bromo-2-fluorophenyl)-2,3-dihydro-1,5-benzothiazepin-4-yl]phenol” 4 and when treated accompanying hydrazine hydrate gave the compound “2-[5-(4-bromo-2-fluorophenyl)-4, 5-dihydro-1H-pyrazol-3-yl]phenol” 5. On the base of spectral data, the buildings of compounds have been built.

Author(s) Details:

S. G. Jagadhani,
P. G. and Research Department of Chemistry, Karmaveer Bhaurao Patil College Vashi, Navi Mumbai, Pin. 400703, India.

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