Comparison of 404 Patients with Right- and Left-sided Colon Cancer in Uganda: Differences in Clinicopathological Profile | Chapter 9 | Research Developments in Medicine and Medical Science Vol. 5

 Introduction: In Western nations right-sided colon cancers (RSCC) present at an earlier age and advanced stage. Researchers believe that skilled is a difference 'tween left-sided colon tumor (LSCC) and RSCC. In Uganda however, it is obscure whether differences lie in the pathological sketch between RSCC and LSCC. The aim of this study search out determine distinctnesses in clinicopathological characteristics between RSCC and LSCC in Ugandan sufferers.Methodology: A cross-sectional study was attended in which colorectal adenocarcinoma formalin-fixed paraffin-entrenched tissue (FFPE) blocks were got from 2008 to 2021. Colorectal specimens were acquired from prospectively recruited patients. In the backward-looking study arm, FFPE blocks and data were acquired from the archives of pathology workshop repositories. Parameters intentional included age, sex, position of the tumour, grade, stage, lymphovascular (LVI) status and histopathological subtype 'tween LSCC and RSCC.Results: Patients with RSCC were not older than those accompanying LSCC (mean age, 56.3 years vs 53.5 age; p=0.170). There was no difference in the stage betwixt RSCC and LSCC. Poorly differentiated tumours were more usually found in RSCC than in LSCC (18.7% vs 10.1%; p=0.038). Moderately and poorly differentiated colonic tumours were more low with RSCC (89.3%) than accompanying LSCC (75.1%) (p=0.007). Younger patients had more poorly differentiated tumours than earlier patients (19.6% against 8.6%; p=0.002). LVI was more common accompanying RSCC than with LSCC (96.8% vs 85.3%; p=0.014). Mucinous adenocarcinoma (MAC) was more common accompanying RSCC (15.8%) compared to LSCC (8.5%) (p=0.056) even though statistical significance was inexact.Conclusions: Clinicopathological features of RSCCs likely to be different from those of LSCCs. RSCCs likely to be guide MAC, a higher grade and LVI status distinguished to LSCC. LSCC and RSCC present predominantly accompanying an advanced stage; therefore, governmental screening programmes for the early discovery of CRC are necessary to reduce death in our Ugandan population.

Author(s) Details:

Richard Wismayer,
Department of Surgery, Masaka Regional Referral Hospital, Masaka, Uganda, Department of Surgery, Faculty of Health Sciences, Habib Medical School, IUIU University, Kampala, Uganda and Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.

Julius Kiwanuka,
Department of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.

Henry Wabinga,
Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.

Michael Odida,
Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda and Department of Pathology, Faculty of Medicine, Gulu University, Gulu, Uganda.

Please see the link here: https://stm.bookpi.org/RDMMS-V5/article/view/9893