Hypertensive Nephropathy: Is Hydrogen Sulfide a Game Changer? | Chapter 10 | Research Developments in Medicine and Medical Science Vol. 3

 Hypertension is a important public health question globally. It is the most universal cause of cardiovascular morbidities and mortalities, with a negative affect renal function. Uncontrolled hypertension causes chronic sort disease, that progresses to end-stage renal disease and someday loss of renal function. Unfortunately, the machine underlying the pathogenesis of hypertension and allure associated nephropathy is still poorly understood. Also worried is the fact that in spite of conventional antihypertensive remedies, achievement of ancestry pressure control and preservation of renal function still remain a general public health challenge in a important subpopulation of hypertensive patients. This plans the need for novel pharmacotherapeutic approaches to curb the problem. Hydrogen sulfide (H2S), the third settled member of the gasotransmitter kin after nitric group of chemical elements and carbon monoxide, has been acknowledged and established to occupy antihypertensive and renoprotective properties, that may show an important therapeutic alternative for hypertensive nephropathy. In this phase, recent verdicts from preclinical studies about therapeutic effect of H2S against hypertensive nephropathy, and allure future clinical use are discussed.

Author(s) Details:

George J. Dugbartey,
Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Accra, Ghana, Department of Surgery, Division of Urology, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada, Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada, Multi-Organ Transplant Program, Western University, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada and Physiology and Pharmacology Unit, Accra College of Medicine, JVX5+FX9, Magnolia St, East Legon, Accra, Ghana.

Please see the link here: https://stm.bookpi.org/RDMMS-V3/article/view/9921