Urinary Albumin Evolution in Saudi Hypertensive Patients with the Current Treatment Local Algorithm an Observational Study | Chapter 12 | Research Developments in Medicine and Medical Science Vol. 2

 An practical study design was chosen to indicate real-life conditions and fall back on the efficacy of pharmacological administration of hypertension in control- ling albuminuria. Microalbuminuria is provoked by hypertension, and if it is not controlled, it can lead to sort damage. Although the primary aim of antihypertensive therapy search out lower blood pressure (BP), it has also existed demonstrated to defeat urine albumin excretion. Antihypertensive drugs' renoprotective belongings include delaying or stopping the progress of albuminuria. A national, multicenter, observational, long study (RATIONAL) evaluated the equivalence between antihy- pertensive situation effect and microalbuminuria evolu- tion over 12 months, between May-2016 and July-2018.Of 409 patients, 60% had unrestrained BP at baseline, just before 34% at 12 months. Over 80% of patients act mono or double antihypertensive therapy, and angiotensin- receptor blockers (ARB) topped the list of drug classes. Albumin–creatinine ratio (ACR) considerably decreased during the whole of the study, indicating that BP control is paramount for fear that target means damage. BP change most strongly correlated accompanying ACR change upon triple remedy (ARB + calcium channel blocker + β-blocker). Importantly, 25% (at 6 months) and 38% (at 12 months) of patients unclaimed back to normoalbuminuria, mostly upon renin-angiotensin system blockers. Around 80% of study cases had also diabetes, a ordinary condition in KSA, which considerably hindered achievement of normoalbuminuria at 12 months. This study present an overview of pharmacological he- agement of hypertension in kidney damage victims, and shed light on high diabetes predominance in this patient people.

Author(s) Details:

Mostafa Qaid Al Shamiri,
Department of Cardiac Science, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Saeed MG Al-Ghamdi,
Department of Internal Medicine, King Abdulaziz Hospital, Jeddah, Saudi Arabia.

Rafif M Farahat,
Department of Internal Medicine, Suliman Habib Hospital Saudi Arabia, Riyadh, Saudi Arabia.

Hosam Nasr El Desouki,
Department of Internal Medicine, United Doctors Hospital, Jeddah, Saudi Arabia.

Mohammed Saeed ElNazer,
Department of Internal Medicine, National Hospital, Riyadh, Saudi Arabia.

Hossam El Deen Moustafa Saleh,
Department of Internal Medicine, Mecca Medical Center, Mekkah, Saudi Arabia.

Ashraf Abdulghani Abo El Naga,
Department of Internal Medicine, Omar Ajaji PC, Riyadh, Saudi Arabia.

Adil Mohammed Salih,
Department of Internal Medicine, Suliman Habib Hospital Saudi Arabia, Riyadh, Saudi Arabia.

Khedr Abdul Aal Mahmoud,
Department of Internal Medicine, New Jedaani Hospital, Jeddah, Saudi Arabia.

Nasim Ahmad Ahmad,
Department of Internal Medicine, Almana Hospital, Jebail, Saudi Arabia.

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