Increasing Trends, Late Presentation and Challenges of Colorectal Cancer in Uganda | Chapter 12 | Research Developments in Medicine and Medical Science Vol. 3

 Introduction: In Uganda, a flow towards an increased occurrence of colorectal cancer (CRC) has happened observed. According to the Kampala Cancer Registry, skilled has been a 4.1% annual allotment increase in the incidence of CRC between female patients. These cases present mainly accompanying late-stage disease accompanying resultant extreme morbidity and death. The aim of our study was to document the burden of CRC, late-stage performance and challenges associated with the increase CRC in Uganda.Methods: A cross-sectional study was completed activity between 2008 and 2021 on 404 subjects with histologically pronounced colorectal adenocarcinoma in central Uganda. Clinical records were inspected, and data were elicited for date of diagnosis, age, sexuality, location of the basic tumour, type of operation and TNM stage. Among 128 CRC subjects recruited and made inquiries, we obtained dossier on whether they had a colonoscopy and either there were colorectal adenomas.Results: The middle age was 54(43-67) years, accompanying 38.9% being ≤ 49 years adult. The male: female sex percentage was 1:1, and advanced-stage ailment constituted 217(60.8%) CRC cases. In all age groups, the repetitiveness of CRC increased from 17 cases in 2008 to 61 cases in 2021. Out of the 128 colleagues who were made inquiries prospectively, only 56(43.8%) had a colonoscopy, among whom 5(8.9%) CRC inmates had colorectal adenomas. Having a family history of CRC (OR=19.83, 95% CI: 2.56-153.74, p=0.004) and GI cancers (OR=6.79, 95% CI, 1.02-45.08, p=0.047) were guide having colorectal adenomatous polyps. Rectal tumours were ultimate common tumours 212(53%), inasmuch as the most common movement performed was a reduced anterior redistribute among these CRC cases 81(30%).Conclusions: The increase in the CRC burden in Uganda should should a public health preference. Increasing the endoscopic and surgical infrastructure to develop the ability to screen, pinpoint and manage CRC is main to improve melancholy and mortality. The extreme number of young individuals pinpointed with CRC is of concern. Therefore, age-appropriate domestic screening directions and education campaigns are unavoidable for Uganda to manage the growing burden of CRC.

Author(s) Details:

Richard Wismayer,
Department of Surgery, Masaka Regional Referral Hospital, Masaka, Uganda, Department of Surgery, Faculty of Health Sciences, Habib Medical School, IUIU University, Kampala, Uganda and Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.

Julius Kiwanuka,
Department of Epidemiology and Biostatistics, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.

Henry Wabinga,
Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.

Michael Odida,
Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda and Department of Pathology, Faculty of Medicine, Gulu University, Gulu, Uganda.

Please see the link here: https://stm.bookpi.org/RDMMS-V3/article/view/9923