SNPs are brief alterations that have the potential to alter proteins' amino acid composition and thus their function. Algorithms that are readily available online can be used to assess the structural and functional effects of these alterations. In the current study, three of these tools—SIFT, PolyPhen, and EFIN—were used with various methodologies, including alignment with homologous sequences, structural characteristic analysis, and random forest method analysis. To determine which nsSNPs might be regarded as harmful, all 232 SNPs found in the dbSNP that were associated with the PGC-1, NRF-1, NRF-2, PPAR, ERR, and MEF-2 genes—the key regulators of the mitochondrial biogenesis pathway—were analysed. SNPs are brief alterations that have the potential to alter proteins' amino acid composition and thus their function. Algorithms that are readily available online can be used to assess the structural and functional effects of these alterations. In the current study, three of these tools—SIFT, PolyPhen, and EFIN—were used with various methodologies, including alignment with homologous sequences, structural characteristic analysis, and random forest method analysis. To determine which nsSNPs might be regarded as harmful, all 232 SNPs found in the dbSNP that were associated with the PGC-1, NRF-1, NRF-2, PPAR, ERR, and MEF-2 genes—the key regulators of the mitochondrial biogenesis pathway—were analysed.
Author(s) Details:
Michelly Ferreira Ribeiro,
Universidade Católica de Brasília, St. de Grandes Áreas Norte 916 - Asa Norte, DF- 70790-160, Brasília.
Sérgio Amorim de Alencar,
Universidade Católica de Brasília, St. de Grandes Áreas Norte 916 - Asa Norte, DF- 70790-160, Brasília.
Please see the link here: https://stm.bookpi.org/RABS-V9/article/view/8345
No comments:
Post a Comment