Computational Analysis of the Functional and Structural Impact of SNPs Present in Genes of the Mitochondrial Biogenesis Pathway | Chapter 4 | Research Aspects in Biological Science Vol. 9

 SNPs are brief alterations that have the potential to alter proteins' amino acid composition and thus their function. Algorithms that are readily available online can be used to assess the structural and functional effects of these alterations. In the current study, three of these tools—SIFT, PolyPhen, and EFIN—were used with various methodologies, including alignment with homologous sequences, structural characteristic analysis, and random forest method analysis. To determine which nsSNPs might be regarded as harmful, all 232 SNPs found in the dbSNP that were associated with the PGC-1, NRF-1, NRF-2, PPAR, ERR, and MEF-2 genes—the key regulators of the mitochondrial biogenesis pathway—were analysed. SNPs are brief alterations that have the potential to alter proteins' amino acid composition and thus their function. Algorithms that are readily available online can be used to assess the structural and functional effects of these alterations. In the current study, three of these tools—SIFT, PolyPhen, and EFIN—were used with various methodologies, including alignment with homologous sequences, structural characteristic analysis, and random forest method analysis. To determine which nsSNPs might be regarded as harmful, all 232 SNPs found in the dbSNP that were associated with the PGC-1, NRF-1, NRF-2, PPAR, ERR, and MEF-2 genes—the key regulators of the mitochondrial biogenesis pathway—were analysed.

Author(s) Details:

Michelly Ferreira Ribeiro,
Universidade Católica de Brasília, St. de Grandes Áreas Norte 916 - Asa Norte, DF- 70790-160, Brasília.

Sérgio Amorim de Alencar,
Universidade Católica de Brasília, St. de Grandes Áreas Norte 916 - Asa Norte, DF- 70790-160, Brasília.

Please see the link here: https://stm.bookpi.org/RABS-V9/article/view/8345

Stimulating Mitochondrial Biogenesis through Exercise - a Viable Way to Prevent Severe Forms of COVID-19? | Chapter 2 | Technological Innovation in Pharmaceutical Research Vol. 3

 Exercise, particularly endurance exercise, can help prevent severe COVID-19 infection by stimulating mitochondrial biogenesis and improving their activity, with these organelles playing a critical role in the disease's etiology. Some drugs and supplements that stimulate mitochondrial biogenesis through exercise (6-hydroxy-2,5,7,8-tetramethylchromane-2- carboxylic acid (Trolox), 3 fatty acids, vitamin C, zinc, vitamin B12, folic acid, magnesium, MitoQ) and others that inhibit it (6-hydroxy-2,5,7,8-tetramethylchromane-2- carboxylic acid (Trolox), 3 fatty acids, vitamin C, zinc, vitamin B12 (acetylsalicylic acid, ibuprofen, acetaminophen). The medical theory that moderate-intensity exercise would stimulate muscle biogenesis would be put into practice. Reduce the chance of acquiring a severe form of COVID-19, and the number of deaths could drop by more than a third.

Author (s) Details

Hagiu Bogdan-Alexandru
Faculty of Physical Education and Sports, “Alexandru Ioan Cuza” University, Iasi, Romania.

View Book :- https://stm.bookpi.org/TIPR-V3/article/view/1145