Assessment of Responsiveness to Cardiac Resynchronization Therapy: A Novel and Simple Exercise Approach | Chapter 12 | Current Innovations in Medicine and Medical Science Vol. 3

 In this work, the heart rate recovery indicator( HRRI), a new exercise test parameter, was estimated as a implicit predictor of cardiac resynchronization remedy response( CRT). We hypothecate that ET may be practical and applicable to study by assaying the time rate between the acceleration and retardation of heart rate. Following implantation and every six months after that, cases who entered a CRT device successively were covered. The minimum and maximum heart rates, as well as the acceleration and retardation ages, were used to measure an trouble test( ET). The rate of acceleration to retardation time( AT/ DT), or HRRI, was calculated and compared to the result. We used logistic retrogression to assess the prophetic value of HRRI for askers andnon-responders to CRT. The area under the wind( AUC) was reckoned to distinguish between positive and negative issues. A aggregate of 109 cases( 74 men, mean age63.3 ±9.8 times) were anatomized; endless long- term emulsion CRT pacing was possible in 65 cases. Cases were assigned to two groups askers andnon-responders(98/11 cases). During a mean follow- up of 36 months, 545 ETs were performed. HRRI was significantly advanced in askers versusnon-responders(3.16 ± 2vs.1.4 ±0.5, p<0.001). The optimal arrestment value for HRRI as a predictor of CRT response was1.51( area under the receiver operating characteristic( ROC) wind = 0.844). Askers had significant left- ventricular( LV) rear redoing( LV end- diastolic volume = 240 ± 90 mLvs. 217 ± 89 mL, p<0.001) and advanced LV ejection bit( 26 ±5.8vs. 35 ±8.7, p<0.001). HRRI calculation during routine ET is useful for the evaluation of responsiveness to CRT. The present study is the first to estimate a new parameter HRRI using HR geste after conclusion of exercise in cases with CRT; birth and minimal HR couldn't prognosticate CRT response, but the analysis of ET graphs in askers versusnon-responders showed a better outgrowth corelated with advanced response in heart HRR.

Author(s) Details:

Alina-Ramona Cozlac,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania and Department of Cardiology, Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.

Lucian Petrescu,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania and Department of Cardiology, Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.

Simina Crisan,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania and Department of Cardiology, Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.

Constantin Tudor Luca,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania and Department of Cardiology, Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.

Cristina Vacarescu,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania and Department of Cardiology, Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.

Caius Glad Streian,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania and Department of Cardiology, Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.

Andra Gurgu,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania.

Angela Dragomir,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania and Department of Cardiology, Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.

Emilia Violeta Goanta,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania.

Radu Vatasescu,
Department of Cardio-Thoracic Pathology, “Carol Davila” University of Medicine and Pharmacy, Dionisie Lupu Street, no. 37, Sector 2, 020021 Bucharest, Romania and Department of Cardiology, Clinical Emergency Hospital Bucharest, 8 Calea Floreasca, 014461 Bucharest, Romania.

Kandara Mohamed Chahine,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania.

Ciprian Rachieru,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania and Department of Internal Medicine, County Emergency Hospital, 5 Gheorghe Dima Street, 300079 Timisoara, Romania.

Dragos Cozma,
Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania and Department of Cardiology, Institute of Cardiovascular Diseases Timisoara, 13A Gheorghe Adam Street, 300310 Timisoara, Romania.

Please see the link here: https://stm.bookpi.org/CIMMS-V3/article/view/8386