Osteoporosis is the most common cause of bone fracture in the senior. Several experimental studies have reported that Nigella sativa( NS) and/ or its main element thymoquinone( TQ) have good goods on osteoporosis and bone mending. We conducted this methodical review to estimate these applicable studies and prove whether NS and/ or TQ have a implicit effect on osteoporosis and can halt the pathogenesis of this complaint or whether this is just a fabrication. A hunt for published studies was conducted in databases similar as Scopus, PubMed, Google Scholar, Web of Science and CINAHIL. The hunt terms included" Nigella sativa, black seed, TQ, osteoporosis, bone mending". originally, 213 papers were uprooted. After reviewing the titles and objectifications, 124 papers( Medline, 43; Scopus, 67; EBSCO, 14) were named for farther analysis. After banning clinical trial studies, reviews, abstract junking and unconnected studies, seven studies were eventually considered suitable for our review. Eventually, seven studies were considered suitable for our review. The total number of creatures used was 220( 150 rats and 70 rabbits) from different experimental studies. Grounded on the results of this methodical review, we conclude that NS or remedy with TQ excerpts can not yet be recommended for osteoporosis and that these data aren't sufficient to reliably rule out the salutary goods of NS on bone development. The α- form of the oestrogen receptor appears to be most important in regulating bone development. thus, farther studies are demanded to probe the specific cellular and molecular targets of NS or TQ using osteoporosis beast models.
Author(s) Details:
Muhamed T. Osman,
Faculty of Medicine and Health Sciences, UCSI University, 2, Avenue, 3, Persiaran Springhill, 71010, Port Dickson, Negeri Sembilan, Malaysia.
Please see the link here: https://stm.bookpi.org/CAPR-V8/article/view/8489
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