Pyrrole Carboxamide Binol Conjugates: Chiral Receptors for Chemical Inversion of L-amino Acids to D- amino Acids| Chapter 4 | Progress in Chemical Science Research Vol. 5

 As chirality conversion reagents (CCRs), four pyrrole carboxamide binol conjugates 1-4 have been used to study the chemical inversion of L-amino acids to D-amino acids. With the help of a resonance-assisted hydrogen bond (RAHB), a Schiff base type imine is formed using this technique, raising the proton's acidity. The heterocylic moiety of the pendant groups and the extra hydrogen bonds between the amino acids and them further stabilise the molecule. All of the pyrrole carboxamine-based receptors 1-4 were discovered to have conversion efficiencies that were comparable to those of the receptors previously reported.

Author(s) Details:

K. Velmurugan,
Fluorensic Materials Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed to be University), Karunya Nagar, Coimbatore-641 114, India.

Lijun Tang,
College of Chemistry and Chemical Engineering, Liaoning Key Laboratory for the Synthesis and Application of Functional Compounds, Bohai University, Jinzhou 121013, P. R. China.

J. Prabhu,
Fluorensic Materials Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed to be University), Karunya Nagar, Coimbatore-641 114, India.

R. Nandhakumar,
Fluorensic Materials Laboratory, Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed to be University), Karunya Nagar, Coimbatore-641 114, India.

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