Endometriosis is a condition in which the tissue that normally lines the uterus grows outside the uterus. Endometriosis is characterized by the presence of tissue attached to the ovaries, fallopian tubes, or intestines. Several recent studies have examined genetic polymorphisms as possible factors in the development of endometriosis. The purpose of this study is to review case-control studies of recent data on genes with nucleotide polymorphisms associated with endometriosis. A PubMed search of endometriosis, polymorphisms, and interleukins found 50 publications between 2001 and 2020. These were classified according to the type of polymorphism tested and whether the results supported or did not support an association with endometriosis. We have found a whole range of conflicting results. About half of the studies surveyed found an association between various polymorphisms and endometriosis. Based on this review, it can be concluded that there are strong gene-environment interactions that could certainly influence approaches to identify genetic variants associated with endometriosis.
Author(s) Details:
Nandhini Balunathan,
Department of Human Genetics, Faculty of Biomedical sciences and technology, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai-116, India.
S. Nandhini,
Department of Human Genetics, Faculty of Biomedical sciences and technology, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai-116, India.
J. Akshaya,
Department of Human Genetics, Faculty of Biomedical sciences and technology, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai-116, India.
Please see the link here: https://stm.bookpi.org/CIMMS-V5/article/view/8467
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