The ideal of the composition is to interpret the goods of folic acid and vitamin B12 collectively or in combination on oxidative stress biomarkers in cardiac towel of rats. cumulative salutary effect of vitamin B12 and folic acid against arsenic- convinced oxidative stress in myocardial towel was set up in manly Wistar rats. NaAsO2 exposure at a cure of 6 mg(i.p.)/ kgb.w./ day for one month displayed significant decline in cardiac glutathione content associated with increased malondialdehyde product. Certain antioxidant enzyme conditioning similar as SOD, catalase, glutathione- S- transferase, glutathione reductase were inhibited after arsenic exposure. also, arsenic treatment significantly increased the nitric oxide product in cardiac towel of rats. Folic acid( 50 µg/ kgb.w./ day) and vitamin B12( 1 µg/ kgb.w./ day) alone or in combination for the last 2 weeks of arsenic treatment displayed distinct defensive effectualness against arsenic intermediated oxidative damage. It was farther noted that combined exposure of folic acid and vitamin B12 displayed synergistic salutary goods against arsenic- convinced oxidative stress in myocardial towel.
Author(s) Details:
Surajit Bhattacharjee,
Amarpur English Medium H.S. School, Gomati Tripura, India.
Sudipta Pal,
Nutritional Biochemistry and Toxicology Laboratory, Department of Human Physiology, Tripura University, Suryamaninagar, West Tripura 799022, India.
Please see the link here: https://stm.bookpi.org/CAPR-V8/article/view/8493
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