This study attempts to assess the most promising approaches for the treatment of obesity while concentrating on the most complex and redundant molecular systems that regulate food intake. Obesity is a chronic multifactorial condition brought on by an imbalance between caloric intake and energy expenditure. The neuroendocrine system is one of the most significant processes controlling human energy intake. The neuroendocrine system is made up of cells that can create amines, peptides, growth factors, and biological mediators known as neurohormones. These mediators interact with the nervous and immunological systems to control a number of biological processes. Although they were discontinued due to major adverse effects, some medications, like sibutramine and rimonabant, that affect the activity of various neuroendocrine mediators (serotonin, noradrenaline, and endocannabinoids), have lately been proven to be beneficial in reducing excess weight. Recently, remarkable outcomes with Glucagon-like Peptide-1 analogues have been attained in this method, exhibiting significant efficacy in weight loss without side effects. A more effective pharmacological therapy approach for treating obesity and other nutritional problems may result from further research into these complex neuroendocrine circuits and their interactions with the hypothalamus in regulating food intake.
Author(s) Details:
Angelo Michele Carella,
Internal Medicine Department, "T. Masselli-Mascia" Hospital - San Severo (Foggia), Italy.
Giuseppe Ciavarrella,
Internal Medicine Department, "T. Masselli-Mascia" Hospital - San Severo (Foggia), Italy.
Matteo Conte,
Internal Medicine Department, "T. Masselli-Mascia" Hospital - San Severo (Foggia), Italy.
Pasquale De Luca,
Internal Medicine Department, "T. Masselli-Mascia" Hospital - San Severo (Foggia), Italy.
Michele Di Pumpo,
Internal Medicine Department, "T. Masselli-Mascia" Hospital - San Severo (Foggia), Italy.
Armando Giancola,
Internal Medicine Department, "T. Masselli-Mascia" Hospital - San Severo (Foggia), Italy.
Teresa Marinelli,
Internal Medicine Department, "T. Masselli-Mascia" Hospital - San Severo (Foggia), Italy.
Martino Nargiso,
Internal Medicine Department, "T. Masselli-Mascia" Hospital - San Severo (Foggia), Italy.
Ernestina Ponziano,
Biochemical Laboratory, Territorial Healthcare Point - Torremaggiore (Fg), Italy.
Angelo Benvenuto,
Internal Medicine Department, "T. Masselli-Mascia" Hospital - San Severo (Foggia), Italy.
Please see the link here: https://stm.bookpi.org/CIMMS-V4/article/view/8399
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