Exploring the Impact of Sodium Arsenite on Lipid Metabolism in Heteropneustes fossilis and the Potential Chelating Effect of Zeolite | Chapter 8 | Innovations in Biological Science Vol. 3

Arsenic toxicity is a global health problem affecting many millions of people. Arsenic, the metal pollutant found naturally in groundwater and unnaturally in mine waste sites and agricultural runoff, has been considered toxic to humans for several millennia. In the present work the effect of different concentrations of sodium arsenite on lipid metabolism in Heteropneustes fossilis, and the chelating effect of synthetic zeolite was studied from liver.
 
Fishes were exposed to two different concentrations of sodium arsenite (200 ml and 400 ml of 1% solution), for 3 different durations (3days, 7 days and 15 days). The concentrations of total Cholesterol (F=6.35>3.84 at 5% P), HDL (F=14.91>6.83 at 5% P), LDL (F=10.11>1.39at 5% P) and triglyceride (F=42.1>19.34 at 5% P) was found significantly increased along with increasing concentration and duration of sodium arsenite. The toxic effect was found recovered after the application of synthetic zeolite for all parameters, i.e., total cholesterol (F=8.04>3.12 at 5%P), HDL (F=14.96>6.83 at 5%P), LDL (F=1.57>1.39 at 5% P) and triglyceride (F=26.28>19.34 at 5% P). Statistical analysis of the results was done by two-way ANOVA.
 
The results suggest that zeolite is a potential compound for decreasing significantly the load of toxicity of arsenic in aquatic fauna.

Author(s) Details:

Jayasree Balasubramanian,
Department of Zoology, St. Thomas College, Bhilai, CG, India.

Anil Kumar,
Department of Zoology, Govt.V.Y.T.PG. Autonomous College, Durg, CG, India.

Please see the link here: https://stm.bookpi.org/IBS-V3/article/view/14248

Arsenic-Induced Oxidative Stress in Cardiac Tissue of Rats: Synergistic Effects of Folic Acid and Vitamin B12| Chapter 5 | Challenges and Advances in Pharmaceutical Research Vol. 8

 The ideal of the composition is to interpret the goods of folic acid and vitamin B12 collectively or in combination on oxidative stress biomarkers in cardiac towel of rats. cumulative salutary effect of vitamin B12 and folic acid against arsenic- convinced oxidative stress in myocardial towel was set up in manly Wistar rats. NaAsO2 exposure at a cure of 6 mg(i.p.)/ kgb.w./ day for one month displayed significant decline in cardiac glutathione content associated with increased malondialdehyde product. Certain antioxidant enzyme conditioning similar as SOD, catalase, glutathione- S- transferase, glutathione reductase were inhibited after arsenic exposure. also, arsenic treatment significantly increased the nitric oxide product in cardiac towel of rats. Folic acid( 50 µg/ kgb.w./ day) and vitamin B12( 1 µg/ kgb.w./ day) alone or in combination for the last 2 weeks of arsenic treatment displayed distinct defensive effectualness against arsenic intermediated oxidative damage. It was farther noted that combined exposure of folic acid and vitamin B12 displayed synergistic salutary goods against arsenic- convinced oxidative stress in myocardial towel.

Author(s) Details:

Surajit Bhattacharjee,
Amarpur English Medium H.S. School, Gomati Tripura, India.

Sudipta Pal,
Nutritional Biochemistry and Toxicology Laboratory, Department of Human Physiology, Tripura University, Suryamaninagar, West Tripura 799022, India.

Please see the link here: https://stm.bookpi.org/CAPR-V8/article/view/8493