Arsenic-Induced Oxidative Stress in Cardiac Tissue of Rats: Synergistic Effects of Folic Acid and Vitamin B12| Chapter 5 | Challenges and Advances in Pharmaceutical Research Vol. 8

 The ideal of the composition is to interpret the goods of folic acid and vitamin B12 collectively or in combination on oxidative stress biomarkers in cardiac towel of rats. cumulative salutary effect of vitamin B12 and folic acid against arsenic- convinced oxidative stress in myocardial towel was set up in manly Wistar rats. NaAsO2 exposure at a cure of 6 mg(i.p.)/ kgb.w./ day for one month displayed significant decline in cardiac glutathione content associated with increased malondialdehyde product. Certain antioxidant enzyme conditioning similar as SOD, catalase, glutathione- S- transferase, glutathione reductase were inhibited after arsenic exposure. also, arsenic treatment significantly increased the nitric oxide product in cardiac towel of rats. Folic acid( 50 µg/ kgb.w./ day) and vitamin B12( 1 µg/ kgb.w./ day) alone or in combination for the last 2 weeks of arsenic treatment displayed distinct defensive effectualness against arsenic intermediated oxidative damage. It was farther noted that combined exposure of folic acid and vitamin B12 displayed synergistic salutary goods against arsenic- convinced oxidative stress in myocardial towel.

Author(s) Details:

Surajit Bhattacharjee,
Amarpur English Medium H.S. School, Gomati Tripura, India.

Sudipta Pal,
Nutritional Biochemistry and Toxicology Laboratory, Department of Human Physiology, Tripura University, Suryamaninagar, West Tripura 799022, India.

Please see the link here: https://stm.bookpi.org/CAPR-V8/article/view/8493

Study about Homocysteine: A Biomarker in Neurodegenerative Diseases | Chapter 10 | Issues and Development in Health Research Vol. 7

 Homocysteine (Hcy) levels in Indians are greater than in Europeans. Hyperhomocysteinemia (HHcy) is an early risk factor for stroke, MI, and other vascular illnesses that is distinct, powerful, graded, and easily quantifiable. A vitamin deficiency or an inherited trait could be the cause. Vitamin B12, Vitamin B6, and folic acid, all of which are required for methionine metabolism, are in short supply in the majority of vegetarian Indians. A dose-dependent connection between mild to moderate increases in plasma Hcy and the risk of neurodegenerative diseases has been established in epidemiological research. Hcy is a neurotoxic substance that serves as a proxy for vitamin insufficiency. Patients with a high Hcy levels have a higher risk of atherosclerotic events. Hyperhomocysteinemia is a common problem among the elderly. According to the findings of this investigation, Hcy levels are higher in patients with neurologic diseases. Both male and female people have statistically significant Hcy levels. Hcy levels are higher in males with neurological disorders. The availability of vitamin-fortified meals, particularly cereals, can help to avoid or delay the onset of age-related neurological disorders in hyperhomocystemic high-risk patients.

Author(S) Details

N. Jayanthi Bai
Department of Laboratory Medicine, SK Hospital, Edappazhinji, Thiruvananthapuram 695006-India.

S. Jayakrishnan
Department of Laboratory Medicine, SK Hospital, Edappazhinji, Thiruvananthapuram 695006-India.

View Book:- https://stm.bookpi.org/IDHR-V7/article/view/4813