Assessment of Chronic Inflammatory Demyelinating Polyneuropathy in Systemic Lupus Erythematosus | Chapter 12 | New Horizons in Medicine and Medical Research Vol. 7

 The central nervous system (CNS) is more commonly affected than the peripheral nervous system in Systemic Lupus Erythematosus (SLE). Neuropsychiatric or CNS signs are widespread, ranging from 24-54 percent, while peripheral nervous system involvement is less common, at roughly 5-27 percent. Chronic Inflammatory Demyelinating Polyradiculopathy (CIDP) is one of the three most common peripheral nerve system involvements in SLE patients, and it can be very disabling.

The goal of this study is to examine all SLE patients who have developed CIDP and report on their clinical symptoms, treatment, and progress, as well as a brief review of the literature on CIDP in SLE patients.

Methods: A retrospective review of all SLE patients diagnosed with CIDP between 2000 and 2015 who were followed up at our centre was conducted. We investigated their clinical presentation, investigations, treatment, response to therapy, and any neurological sequelae in their medical records.

There were 512 case notes analysed in total. These four patients, all between the ages of 26 and 46, presented with CIDP (3 females and 1 man). Three of the patients had transverse myelitis, while the fourth had acute motor and sensory axonal neuropathy. All of the patients were given high-dose corticosteroids, three of them were given cyclophosphamide, and the other was given mycophenolate mofetil. One patient had a complete recovery, two had persistent but improving numbness, and the third had lingering weakness. Two of our patients acquired CIDP shortly after being diagnosed with SLE, while the other two developed it much later in the course of their disease.

Conclusion: Involvement of the peripheral nerve system in SLE can have major disabling consequences. Early detection and treatment are critical for reducing neurological consequences.

Author(S) Details

Rozita Mohd
Nephrology Unit, Pusat Perubatan Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000, Cheras Kuala, Lumpur, Malaysia.

Fatimah Zanirah Nordin
Nephrology Unit, Pusat Perubatan Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000, Cheras Kuala, Lumpur, Malaysia.

Rizna Cader
Nephrology Unit, Pusat Perubatan Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000, Cheras Kuala, Lumpur, Malaysia.

View Book:- https://stm.bookpi.org/NHMMR-V7/article/view/6670

Study about Homocysteine: A Biomarker in Neurodegenerative Diseases | Chapter 10 | Issues and Development in Health Research Vol. 7

 Homocysteine (Hcy) levels in Indians are greater than in Europeans. Hyperhomocysteinemia (HHcy) is an early risk factor for stroke, MI, and other vascular illnesses that is distinct, powerful, graded, and easily quantifiable. A vitamin deficiency or an inherited trait could be the cause. Vitamin B12, Vitamin B6, and folic acid, all of which are required for methionine metabolism, are in short supply in the majority of vegetarian Indians. A dose-dependent connection between mild to moderate increases in plasma Hcy and the risk of neurodegenerative diseases has been established in epidemiological research. Hcy is a neurotoxic substance that serves as a proxy for vitamin insufficiency. Patients with a high Hcy levels have a higher risk of atherosclerotic events. Hyperhomocysteinemia is a common problem among the elderly. According to the findings of this investigation, Hcy levels are higher in patients with neurologic diseases. Both male and female people have statistically significant Hcy levels. Hcy levels are higher in males with neurological disorders. The availability of vitamin-fortified meals, particularly cereals, can help to avoid or delay the onset of age-related neurological disorders in hyperhomocystemic high-risk patients.

Author(S) Details

N. Jayanthi Bai
Department of Laboratory Medicine, SK Hospital, Edappazhinji, Thiruvananthapuram 695006-India.

S. Jayakrishnan
Department of Laboratory Medicine, SK Hospital, Edappazhinji, Thiruvananthapuram 695006-India.

View Book:- https://stm.bookpi.org/IDHR-V7/article/view/4813