With this book chapter, we aimed to review the current understanding of the fascinating interaction between autophagy and the adhesion-related mechanotransduction machinery, which we termed "Mechanoautophagy." The focal adhesions, also known as integrin-mediated adhesions, sense mechanical and chemical signals from the extracellular matrix in both healthy and pathological situations. Cells are exposed to various mechanical stresses and physical cues coming from the environment, and they respond to them. One of the important participants in this interaction, which has been seen to differentially govern a range of cellular functions for the maintenance of homeostasis, is autophagy. Additionally, it has been proposed that autophagy controls how the cells interact with their surroundings mechanically. The interesting interaction between autophagy and the mechanotransduction system connected to cell adhesions, which we refer to as "Mechanoautophagy," is summarised in this minireview. We have only just begun to understand how autophagy is involved in a vast array of mechanically related cellular activities. The study of mechanoautophagy is also necessary in a wide range of physiological and pathological contexts, such as development and/or obesity, where the study of autophagy and mechanical forces per se, but not their synergy, has been taken into account. Additionally, we have only discussed the role of mechanoautophagy in cancer transformation.
Author(s) Details:
Andrea Ravasio,
Institute for Biological and Medical Engineering Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
Eugenia Morselli,
Department of Basic Sciences, Faculty of Medicine and Sciences, Universidad San Sebastián, Santiago, Chile.
Cristina Bertocchi,
Laboratory for Molecular Mechanics of Cell Adhesion, Department of Physiology Pontificia Universidad Católica de Chile, Santiago, Chile and Graduate School of Engineering Science, Osaka University, Japan.
Please see the link here: https://stm.bookpi.org/RABS-V9/article/view/8346
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