Highlighting the Role of Acalypha indica Linn. Extract on Heart Rates with Myasthenia Gravis Rat Model | Chapter 5 | Challenges and Advances in Pharmaceutical Research Vol. 4

In the current investigation, acetylcholinesterase and the AChR were found to be adversely affected by root extract in animal models. When rocuronium bromide was given into Sprague-Dawley rats, the autonomic nervous system on the heart muscle, in this instance, is heart rate (HR). Myasthenia gravis (MG) is an autoimmune condition affecting the neuromuscular junction (NMJ) that results in fatigue and skeletal muscle weakening by antibodies attacking postsynaptic membrane components. Acetylcholine serves as a neurotransmitter in the autonomic nervous system. Heart failure, arrhythmia, and sudden death can occur as a result of immune assault on striated cardiac muscle. Heart rate (HR) involvement has been suggested and documented, but no evidence linking MG to altered cardiac function has been discovered.

Rocuronium, prostigmine, and Acalypha indica (AI) Linn. are employed in this investigation of experimental autoimmune MG (EAMG) in comparison to HR.

Injecting EAMG with rocuronium 10 mg/kg body weight caused sympathetic activity of HR variability, according to the study's findings (BW).

Measures of short-term fluctuations in HR variability were substantially shown to be rising in just 10 minutes, indicating parasympathetic dysfunction.

We come to the conclusion that cholinergic transmission is more widely disrupted in MG than previously believed. Additionally, AI was administered orally.

Similar results may be obtained by administering prostigmine at a dose of 10 mg/kg BW, which can lower heart rate. It requires the therapeutic development for MG employing herbal components of AI due to the fact that the pharmaceutical therapy of MG is ineffective. The findings point to the necessity of frequent autonomic functions testing in MG patients in order to both identify those who are at high risk and prompt early consideration of cardioprotection and long-term follow-up investigations. Furthermore, rocuronium, prostigmine, and AI are linked to HR on EAMG based on these studies, indicating that AI and prostigmine have comparable effects. Advanced study is needed in order to know and understand more.

Author (s) Details:

Desak Gede Budi Krisnamurti,
Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Rani Wardani Hakim,
Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Radiana Dhewayani Antarianto,
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Siti Farida,
Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Erni Hernawati Purwaningsih,
Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Jan Sudir Purba,
Department of Neurology, Universitas Indonesia, Jakarta, Indonesia.

Please see the link here: https://stm.bookpi.org/CAPR-V4/article/view/7507