Antioxidant Levels and Inhibition of Cancer Cell Proliferation In-vitro by Extracts from Peltophorum pterocarpum Collected in Vietnam | Chapter 6 | Current Practice in Medical Science Vol. 4

A common ornamental and deciduous tree, Peltophorum pterocarpum is endemic to tropical South-Eastern Asian nations. Examining the effects of 70% ethanolic extracts of P. pterocarpum leaves (LPP) and stem bark on low-density lipoprotein oxidation and cytotoxic activity against cancer cell lines is the goal of this study (SPP). The outcomes demonstrated that both LPP and SPP, in a dose-dependent way, reduced the production of thiobarbituric acid reactive compounds as well as Cu2+-mediated low-density lipoprotein. Additionally, MIA PACA2, A549, KG, HL-60, and CRF-SBA were significantly toxic to by SPP, with IC50 values ranging from 118.5 to 255.0 g/mL. KG, HL-60, and CCRF-SBA were all susceptible to the cytotoxic effects of LPP, with IC50 values ranging from 146.0 to 228.1 g/mL. In HL-60 and CCRF-SBA cells, SPP also caused cytotoxicity by activating the apoptotic pathway. These results showed that SPP could prevent the onset and progression of atherosclerosis and leukaemia in people.

Author(s) Details:

Dao Cuong To,

Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong district, Hanoi 12116, Vietnam and Phenikaa Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, 167 Hoang Ngan, Cau Giay District, Hanoi 11313, Vietnam.

Phi Hung Nguyen,

Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet street, Cau Giay District, Hanoi 122100, Vietnam.

Kim Thuong Pham Van,

School of Medicine and Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son District, Danang city 550000, Vietnam.

Loi Huynh,

School of Medicine and Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son District, Danang city 550000, Vietnam.

Manh Hung Tran,

School of Medicine and Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son District, Danang city 550000, Vietnam.

Please see the link here: https://stm.bookpi.org/CPMS-V4/article/view/7361