Recent Development and Validation of Sodium Nitroprusside in Visible Spectrophotometric Determination of Triprolidine Hydrochloride | Chapter 1 | Challenges and Advances in Chemical Science Vol. 2

 The assay of Triprolidine Hydrochloride using Sodium nitroprusside is created utilising a simple and sensitive extractive visible spectrophotometric approach.

Methods: Based on the colour development with amino groups, the presence of a basic substance could be attributed to the formation of an inner complex that replaces H2O with the drug's tertiary amino group.

The coloured goods have a maximum absorption wavelength of 447 nm. In the concentration ranges (40–240) g/ml, regression analysis of Beer–Lambert plots revealed high correlation with correlation coefficients of 0.994. Sandell's sensitivities are 2.6373102 (1 mole cm1), and the molar absorptivity is 1.1938104 (g cm2). The results of recovery experiments range from 99.708 to 99.786.

Conclusion: The method can be used to estimate the drug's concentration in the presence of additional components that are commonly found in formulations. The suggested approach describes a novel method for measuring Triprolidine Hydrochloride (TPH) in medicines.

Author (S) Details

M. L. N. Acharyulu
Department of Basic Sciences and Humanites, Centurion University of Technology and Management, Gidijala, Andhra Pradesh, India.

P. V. S. R. Mohana Rao
Department of Engineering Chemistry, A. U. College of Engineering (A), Visakhapatnam, Andhra Pradesh, India.

I. Siva Rama Koti
Department of Basic Sciences and Humanites, Centurion University of Technology and Management, R. Sitapur, Odisha, India.

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