Colloidal Nanoparticles Used as Anticancer Drug Carriers | Chapter 3 | Advanced Concepts in Pharmaceutical Research Vol. 1

 Cancer is a philosophically significant disease, because the incidence of oncological diseases is steadily growing worldwide. This makes necessary the search for alternative healing strategies beyond usual chemo- and radiotherapy to reduce adverse belongings, in particular high toxicity. Molecular chemotherapeutics have cytotoxic belongings on both cancer containers and healthy dividing containers, in particular those of the immune order. The main problem of a destructive agent, selectivity, can be answered by using some differentiations of cancer cells from healthful cells. One such dissimilarity is their ability to phagocytose colloidal particles of submicron diameter. For this purpose, it is necessary to construct a ship that carries airplanes particles through which microscopic chemotherapeutics can be brought and released inside the cancer container.. Chemotherapeutic agents can be transported by nanoparticles, hydrogels, composed nanoparticle-hydrogels, micelles and liposomes. In this way, to achieve extreme transport efficiency, uptake and discrimination composite particles should be groomed starting from their physicochemical properties. The main focus concerning this book chapter is likely to the surface properties as hydrophilicity/hydrophobicity and electric charge of nanoparticles made from metal and dielectric substances: metals (golden, silver), metal-oxides of iron, container, titanium and zirconium, silicates (quartz), alumosilicates (montmorillonite, kaolinite), and carbonates. The physicochemical properties of the nanoparticles are emphasized in consideration of assist researchers in choosing appropriate nanoparticles for adsorption of drugs accompanying hydrophilic and hydrophobic organic molecules in consideration of synthesize composite atoms for using as carriers of various anticancer agents.

Author(s) Details:

Alexandar M. Zhivkov,
Institute of Physical Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 11, Sofia 1113, Bulgaria.

Svetlana H. Hristova,
Department of Medical Physics and Biophysics, Medical Faculty, Medical University – Sofia, Zdrave Str. 2, Sofia 1431, Bulgaria.

Trifon T. Popov,
Medical Faculty, Medical University – Sofia, Zdrave Str. 2, Sofia 1431, Bulgaria.

Please see the link here: https://stm.bookpi.org/ACPR-V1/article/view/12074