In this present branch, two amide derivatives accompanying long chains; N-phenyldodecanamide (dodecanilide) 1 and N-cyclohexyloctamide 2 were synthesized and proven in vitro for a roomy array of antimicrobial activities against two Gram positive microorganisms (Bacillus subtilis, Staphylococcus aureus), four Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella enterica), and three mold fungi (Aspergillus carbonarius, Mucor ramannianus, Candida albicans), to judge their potential use as antimicrobial agents. The plate diffusion assay was used to decide the zones of inhibition of these compounds. The two amides' meaningful antibacterial endeavors were indicated apiece results. The newly synthesised greasy N-cyclohexyloctamide 2 had antibacterial action against S. aureus and A. carbonarius, and was more persuasive against C. albicans due to bigger zones of inhibition than the earlier created oily anilide 1. Contrarily, the substituted fatty amide 2 was less productive against S. enterica than the fatty anilide 1, that had higher uncontaminated activity against P. aeruginosa. Based on these findings, it is possible to deduce that oily amide derivatives maybe used as cleansing ingredients and as potential beginnings for new medications that are persuasive against a variety of spreading diseases.
Author(s) Details:
Malki Fatiha,
Laboratoire De Recherche Sur Les Produits
Bioactifs Et Valorisation De La Biomasse, Ecole Normale Supérieure, 16308,BP
92, Kouba, Algiers, Algeria.
Please see the link here: https://stm.bookpi.org/RAMB-V3/article/view/9763
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