Ulipristal in Fibroids: A Recent Study | Chapter 11 | Recent Developments in Medicine and Medical Research Vol. 14

 Symptomatic uterine fibroids are treated with surgery. Tranexamic acid, OC tablets, Progesterone, LNG IUS, and GnRH analogues are used as a temporary measure before to surgery. SPRMs (Selective Progesterone Receptor Modulators) are a novel family of medicines that can be used in medicine. Ulipristal acetate is an SPRM that has been approved for the treatment of fibroids in clinical trials.

The study was place in a tertiary care facility in South India. Fifty women with fibroids and menorrhagia who are awaiting definitive surgery or pre-operative treatment to prepare for surgery or who desire medical treatment are the study's participants. At the start of treatment, blood loss was measured using the PBAC scale. The number and size of the fibroids were determined using ultrasonography. Symptoms that went along with it were recorded. Uripristal acetate 5 mg was given every day for three months. Blood loss, amenorrhoea, and fibroids volume were all measured after three months of treatment. The negative impacts were recorded. Their menstrual cycle was monitored for another three months to see if it had restarted. Blood loss was reduced by 88 percent on average. 82 percent of women suffered from amenorrhoea. The fibroids' volume was reduced by 28.2 percent. There were no negative consequences. Two amenorrhic women reported experiencing hot flushes. After 30-40 days, 47 returned to menstruation, with normal or slightly reduced bleeding. Dymenorrhea and fibroids' pressure sensations were relieved. The findings of the study were compared to the findings of other investigations. A 5 mg dose of ulipristalis is just as effective as a 10 mg dose in managing menorrhagia and decreasing fibroid size.

Author(S) Details

Alla Satyanarayana Reddy
Department of Obstetrics & Gynaecology, Vinayaka Missions Medical College & Hospital, Karaikal, India.

S. Manjula
Department of Obstetrics & Gynaecology, Vinayaka Missions Medical College & Hospital, Karaikal, India and Vinayaka Mission`s Research Foundation VMRF (DU), India.

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