Advances in Personalized Therapy: Co-targeting Intracellular Immune checkpoints in Controlling Acute Myeloid Leukemia | Chapter 12 | Recent Developments in Medicine and Medical Research Vol. 14

 In comparison to other traditional therapies, personalised medicine is garnering a lot of attention because of its more particular focused approach. Precision therapies have had a lot of success in managing specific subtypes of leukaemia in the last few decades. This chapter outlines how tailored medicines are highly effective at identifying specific tumour antigens and regulating haematological illnesses, particularly acute myeloid leukaemia (AML). We've talked about how biosimilar antibody engineering and CAR T-cell engineering are helping to control relapsed AML. Furthermore, the combined effect of immune checkpoint targeted therapy in further increasing the efficacy of biological medicines has been highlighted. We've also discussed how epitranscriptomics could be exploited as a possible "intracellular checkpoint" target for enhancing immune cell efficacy in the tumour microenvironment. Epitranscriptomics is described as the study of physiological changes or modifications in cells by focusing on m6A-modifiers (writer/editor, remover/eraser, and reader/effector) without affecting the RNA/DNA sequence. Targeting these machines could offer a high therapeutic utility in halting disease progression in its early stages, and it could be transformed into a druggable candidate. By establishing the importance of bi-specific biosimilar antibodies, CAR T-cell therapy, and epitranscriptomics in prolonging the survival of AML patients, we have demonstrated the advancement in personalised medicine.

Author(S) Details

Sunil Kumar
Department of Biological Sciences, Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea and Science Research Center (SRC) for Immune Research on Non-lymphoid Organ (CIRNO), Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea.

Muhammad Umer Ashraf
Department of Biological Sciences, Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea and Science Research Center (SRC) for Immune Research on Non-lymphoid Organ (CIRNO), Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea.

Ashok Kumar Aman
Department of Pediatrics, Bokaro General Hospital, Sector-IV, Bokaro Steel City, Jharkhand, 827004, India.

Yong-Soo Bae
Department of Biological Sciences, Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea and Science Research Center (SRC) for Immune Research on Non-lymphoid Organ (CIRNO), Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea.

View Book:- https://stm.bookpi.org/RDMMR-V14/article/view/4991