Telomerase is an enzyme that stretches and protects the ends of chromosomes, known as telomeres. This reverse transcriptase function is essential for dividing cells whose telomeres are constantly shortening. TERT (Telomerase Reverse Transcriptase) has a number of non-canonical roles in addition to its canonical role in preserving telomeres in dividing cells. Importantly, the RNA component of telomerase, TERC, is downregulated early in human brain development, resulting in telomerase activity loss in all but neural stem cells. The telomerase protein TERT, on the other hand, is found in human brain neurons throughout one's life. TERT is the most prevalent telomerase subunit in the brain, and it is responsible for a variety of protective processes such as better stress responses and accelerated toxicity protein degradation. The current review discusses some recent results about telomerase in the brain, as well as their potential implications for neurodegenerative illnesses and novel therapeutic techniques.
Author(S) DetailsGabriele Saretzki
Biosciences Institute, Newcastle University, Campus for Ageing and Vitality, NE4 5Pl Newcastle upon Tyne, UK.
View Book:- https://stm.bookpi.org/RDMMR-V9/article/view/4603
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