Study on Laparoscopic Partial Nephrectomy: An Approach Towards Surgical Technique, Postoperative Survival, and Tumor Characterization According to VEGF Immunostaining | Chapter 8 | Highlights on Medicine and Medical Science Vol. 7

 In two papers published in 1993, laparoscopic partial nephrectomy (LPN) was first documented. Despite the fact that the surgical procedure was novel in terms of approach, it attempted to replicate open surgery's oncological and reconstructive concepts. In this series, we provide oncological findings and establish 5-year postoperative survival. Due to the crucial role of angiogenesis in the aetiology of renal carcinomas, we also measure the presence of the "Vascular Endothelial Growth Factor" (VEGF). We conducted 67 LPN for localised kidney malignancies at the Decentralized General Acute Zonal Hospital "Evita Pueblo" in Berazategui between 2005 and 2013. Transperitoneal laparoscopic partial nephrectomy was performed as the surgical procedure. The patients were put on a follow-up regimen after surgery. Our surgical procedure allowed us to achieve an average duration of 107 minutes and an ischemia time of 19 minutes, according to the results. Hemorrhage was the most common complication, occurring in 7.6% of patients. Although haemorrhage and bile duct injury necessitated conversion to open surgery in two patients, conversion to radical surgery was not required in any of the cases. Overall survival in clinical stages T1a / T1b was 96.7 percent after 5 years. We may conclude that our LPN technique provides oncological results that are comparable to those of other open or robotic surgical techniques, while also offering the benefits of minimally invasive surgery at a reasonable cost. Postoperative survival is connected to the degree of cell differentiation, which was demonstrated in the current study by immunostaining with VEGF, where we found that tumours with higher marking intensity are directly correlated with worse postoperative survival (p 0.002).

Author (S) Details

Santinelli Flavio
Hospital Zonal General de Agudos Descentralizado 'Evita Pueblo', Berazategui, Buenos Aires, Argentina.

Baldarena Claudio
Hospital Zonal General de Agudos Descentralizado 'Evita Pueblo', Berazategui, Buenos Aires, Argentina.

Mias Fernando
Hospital Zonal General de Agudos Descentralizado 'Evita Pueblo', Berazategui, Buenos Aires, Argentina.

López Gustavo
Hospital Zonal General de Agudos Descentralizado 'Evita Pueblo', Berazategui, Buenos Aires, Argentina.

Inda Ana
Faculty of Medical Sciences, Chair of Cytology, Histology and Embryology 'A', National University of La Plata, Buenos Aires, Argentina.

García Marcela
Faculty of Medical Sciences, Chair of Cytology, Histology and Embryology 'A', National University of La Plata, Buenos Aires, Argentina.

Colaci Pablo
Hospital Zonal General de Agudos Descentralizado 'Evita Pueblo', Berazategui, Buenos Aires, Argentina and Faculty of Medical Sciences, Chair of Cytology, Histology and Embryology 'A', National University of La Plata, Buenos Aires, Argentina.

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