Study on the of Anagrelide on Platelet Factor 4 and Vascular Endothelial Growth Factor Levels in Patients with Essential Thrombocythemia | Chapter 19 | Recent Developments in Medicine and Medical Research Vol. 4

 The myeloproliferative neoplasm Essential Thrombocythemia (ET) is characterised by a high platelet count and platelet activation connected to angiogenesis. Platelet activation is promoted by vascular endothelial growth factor (VEGF), and active platelets emit VEGF, according to research. Anagrelide (ANA) is a new medication that lowers platelet counts and inhibits platelet activation.

Platelet count, platelet factor 4 (PF4) levels, as an indicator of platelet activation, and corrected platelet VEGF (VEGFPLT), as an indicator of angiogenesis-related platelet activation, were investigated in ET patients treated with hydroxyurea (HU) and interferon (IFN) or ANA in combination with antiaggregants. Prior to treatment, all patients had higher platelets, PF4, and VEGFPLT levels than controls. All patients had lower platelets after therapy, although PF4 and VEGFPLT were higher in the HU and IFN- groups compared to controls, and normal in the ANA group. There was no association between PF4 and platelets, however PF4 and VEGFPLT had a positive correlation.

If the findings are verified in larger research, ANA may have anti-platelet and anti-angiogenic characteristics.

Author(S) Details

Rossella R. Cacciola
Institute of Hematology, University of Catania, Catania, Italy.

Ernesto Di Francesco
Institute of Hematology, University of Catania, Catania, Italy.

Rosario Giustolisi
Institute of Hematology, University of Catania, Catania, Italy.

Emma Cacciola
Institute of Hematology, University of Catania, Catania, Italy.

View Book:- https://stm.bookpi.org/RDMMR-V4/article/view/4184

Study on Laparoscopic Partial Nephrectomy: An Approach Towards Surgical Technique, Postoperative Survival, and Tumor Characterization According to VEGF Immunostaining | Chapter 8 | Highlights on Medicine and Medical Science Vol. 7

 In two papers published in 1993, laparoscopic partial nephrectomy (LPN) was first documented. Despite the fact that the surgical procedure was novel in terms of approach, it attempted to replicate open surgery's oncological and reconstructive concepts. In this series, we provide oncological findings and establish 5-year postoperative survival. Due to the crucial role of angiogenesis in the aetiology of renal carcinomas, we also measure the presence of the "Vascular Endothelial Growth Factor" (VEGF). We conducted 67 LPN for localised kidney malignancies at the Decentralized General Acute Zonal Hospital "Evita Pueblo" in Berazategui between 2005 and 2013. Transperitoneal laparoscopic partial nephrectomy was performed as the surgical procedure. The patients were put on a follow-up regimen after surgery. Our surgical procedure allowed us to achieve an average duration of 107 minutes and an ischemia time of 19 minutes, according to the results. Hemorrhage was the most common complication, occurring in 7.6% of patients. Although haemorrhage and bile duct injury necessitated conversion to open surgery in two patients, conversion to radical surgery was not required in any of the cases. Overall survival in clinical stages T1a / T1b was 96.7 percent after 5 years. We may conclude that our LPN technique provides oncological results that are comparable to those of other open or robotic surgical techniques, while also offering the benefits of minimally invasive surgery at a reasonable cost. Postoperative survival is connected to the degree of cell differentiation, which was demonstrated in the current study by immunostaining with VEGF, where we found that tumours with higher marking intensity are directly correlated with worse postoperative survival (p 0.002).

Author (S) Details

Santinelli Flavio
Hospital Zonal General de Agudos Descentralizado 'Evita Pueblo', Berazategui, Buenos Aires, Argentina.

Baldarena Claudio
Hospital Zonal General de Agudos Descentralizado 'Evita Pueblo', Berazategui, Buenos Aires, Argentina.

Mias Fernando
Hospital Zonal General de Agudos Descentralizado 'Evita Pueblo', Berazategui, Buenos Aires, Argentina.

López Gustavo
Hospital Zonal General de Agudos Descentralizado 'Evita Pueblo', Berazategui, Buenos Aires, Argentina.

Inda Ana
Faculty of Medical Sciences, Chair of Cytology, Histology and Embryology 'A', National University of La Plata, Buenos Aires, Argentina.

García Marcela
Faculty of Medical Sciences, Chair of Cytology, Histology and Embryology 'A', National University of La Plata, Buenos Aires, Argentina.

Colaci Pablo
Hospital Zonal General de Agudos Descentralizado 'Evita Pueblo', Berazategui, Buenos Aires, Argentina and Faculty of Medical Sciences, Chair of Cytology, Histology and Embryology 'A', National University of La Plata, Buenos Aires, Argentina.

View Book :- https://stm.bookpi.org/HMMS-V7/article/view/2036

Vitamin D and VEGF Serum Levels Association with Adult-onset Diabetes Complications | Chapter 8 | Current Topics in Medicine and Medical Research Vol.4

 

Background: Vitamin D insufficiency is defined as serum 25-hydroxyvitamin D (25(OH)D) levels

below 30 ng/mL and is common among patients with adult-onset diabetes and the elderly.

Aim & Objectives: The purpose of this study was to investigate clinically meaningful associations

implicating low Vitamin D blood levels and vascular endothelial growth factor (VEGF) levels in adultonset

diabetes (DM type 2).

Methods: Serum 25(OH)D and VEGF levels were determined in 40 patients with DM type 2. Their

correlation with markers of advanced diabetic disease (amputation, diabetic foot, proliferative diabetic

retinopathy, insulin dependence) as well as with serum biochemical parameters was examined.

Subanalysis was performed separately on men and women.

Results: Compared with males, female patients exhibited lower 25(OH)D levels (p<0.0001) but

higher serum VEGF (p=0.018). There was a trend towards an inverse Vitamin D - VEGF association.

Subanalysis on women showed low serum 25(OH)D levels strongly associated with amputation

(p=0.003). High serum VEGF levels were associated with amputation (p=0.038), and marginally with

diabetic foot (p=0.058), insulin dependence (p=0.084) and proliferative diabetic retinopathy (p=0.086).

Higher serum 25(OH)D levels were associated with serum uric acid (p=0.007), calcium (p=0.042) and

albumin levels (p=0.033). Subanalysis on men demonstrated positive correlation between 25(OH)D

levels, albumin (p=0.004) and calcium levels (p=0.060, borderline association).

Conclusion: The association between low serum 25(OH)D levels and amputation in women may be

inscribed into the wider context portraying vitamin D insufficiency as a poor prognostic factor. Vitamin

D insufficiency may exert gender-specific effects in the context of adult-onset diabetes.

 

Author (s) Details

Nikol Panou

1st Department of Surgery, Athens University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st, Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the Bones, 2 Nikis St., Athens, 14561, Greece.

Sotirios Georgopoulos

1st Department of Surgery, Athens University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st, Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the Bones, 2 Nikis St., Athens, 14561, Greece.

Marios Panou

1st Department of Surgery, Athens University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st, Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the Bones, 2 Nikis St., Athens, 14561, Greece.

Theodoros N. Sergentanis

1st Department of Surgery, Athens University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st, Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the Bones, 2 Nikis St., Athens, 14561, Greece.

Alexandros Papalampros

1st Department of Surgery, Athens University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st, Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the Bones, 2 Nikis St., Athens, 14561, Greece.

Georgios Maropoulos

1st Department of Surgery, Athens University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st, Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the Bones, 2 Nikis St., Athens, 14561, Greece.

Nikolaos Tentolouris

1st Department of Surgery, Athens University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st, Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the Bones, 2 Nikis St., Athens, 14561, Greece.

Frangiska Sigala

1st Department of Surgery, Athens University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st, Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the Bones, 2 Nikis St., Athens, 14561, Greece.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/248