Background: Vitamin D insufficiency
is defined as serum 25-hydroxyvitamin D (25(OH)D) levels
below 30 ng/mL and is common among
patients with adult-onset diabetes and the elderly.
Aim & Objectives: The purpose of this
study was to investigate clinically meaningful associations
implicating low Vitamin D blood levels
and vascular endothelial growth factor (VEGF) levels in adultonset
diabetes (DM type 2).
Methods: Serum 25(OH)D and VEGF
levels were determined in 40 patients with DM type 2. Their
correlation with markers of advanced
diabetic disease (amputation, diabetic foot, proliferative diabetic
retinopathy, insulin dependence) as well
as with serum biochemical parameters was examined.
Subanalysis was performed separately on
men and women.
Results: Compared with males,
female patients exhibited lower 25(OH)D levels (p<0.0001) but
higher serum VEGF (p=0.018). There was a
trend towards an inverse Vitamin D - VEGF association.
Subanalysis on women showed low serum
25(OH)D levels strongly associated with amputation
(p=0.003). High serum VEGF levels were
associated with amputation (p=0.038), and marginally with
diabetic foot (p=0.058), insulin
dependence (p=0.084) and proliferative diabetic retinopathy (p=0.086).
Higher serum 25(OH)D levels were
associated with serum uric acid (p=0.007), calcium (p=0.042) and
albumin levels (p=0.033). Subanalysis on
men demonstrated positive correlation between 25(OH)D
levels, albumin (p=0.004) and calcium
levels (p=0.060, borderline association).
Conclusion: The association between
low serum 25(OH)D levels and amputation in women may be
inscribed into the wider context
portraying vitamin D insufficiency as a poor prognostic factor. Vitamin
D insufficiency may exert gender-specific
effects in the context of adult-onset diabetes.
Author (s) Details
Nikol Panou
1st Department of Surgery, Athens
University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st,
Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the
Bones, 2 Nikis St., Athens, 14561, Greece.
Sotirios Georgopoulos
1st Department of Surgery, Athens
University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st,
Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the
Bones, 2 Nikis St., Athens, 14561, Greece.
Marios Panou
1st Department of Surgery, Athens
University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st,
Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the
Bones, 2 Nikis St., Athens, 14561, Greece.
Theodoros N. Sergentanis
1st Department of Surgery, Athens
University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st,
Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the
Bones, 2 Nikis St., Athens, 14561, Greece.
Alexandros Papalampros
1st Department of Surgery, Athens
University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st,
Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the
Bones, 2 Nikis St., Athens, 14561, Greece.
Georgios Maropoulos
1st Department of Surgery, Athens
University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st,
Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the
Bones, 2 Nikis St., Athens, 14561, Greece.
Nikolaos Tentolouris
1st Department of Surgery, Athens
University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st,
Athens, 11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the
Bones, 2 Nikis St., Athens, 14561, Greece.
Frangiska Sigala
1st Department of Surgery, Athens
University School of Medicine, Laikon General Hospital, 17 Ag. Thoma st, Athens,
11527, Greece and KAT Hospital, Laboratory of Metabolic Diseases of the Bones,
2 Nikis St., Athens, 14561, Greece.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/248
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