CXCR4 Expression in Gastric Cancer and Bone Marrow | Chapter 4 | Highlights on Medicine and Medical Science Vol. 2

 CXCR4 is a chemokine receptor that is specific for stromal-derived factor-1 (SDF-1, CXCL12) and is involved in the spread and progression of a number of different tumors. Although evidence suggests that CXCR4 and SDF-1 expression can be used to assess the risk of gastric cancer progression, their impact on the occurrence and progression of gastric cancer (GC) requires further investigation. The current study examined the relationship of CXCR4 expression in both GC and bone marrow (BM) with clinical characteristics using immunohistochemistry, immunocytochemistry, NMR-spectroscopy, and zymography, as well as overall The overall survival (OS) of 65 GC patients was studied. CXCR4 was found to be expressed in 78.5 percent of GC specimens and was associated with tumor hypoxia (p0.05), VEGF expression (p0.01), and gelatinase activity (p0.05). CXCR4-positive cells in the GC were found in 80 percent of patients with disseminated tumor cells (DTCs) in the BM. CXCR4 expression in the brain was linked to DTCs, particularly in patients with M0. Patients with CXCR4-positive tumors had a lower overall survival (OS) than those with CXCR4-negative tumors (p=0.037). CXCR4 expression in the brain was not linked to OS. Patients with M0 and both CXCR4-positive BM and DTCs have a higher risk of a poor outcome (P = 0.03).

Author (s) Details

Dmitry Osinsky
City Clinical Oncological Center, Verchovynna Street 69, Kiev 03115, Ukraine.

Larissa Bubnovskaya
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Vasylkivska Street 45, Kiev 03022, Ukraine.

Dr. Irina Ganusevich,
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Vasylkivska Street 45, Kiev 03022, Ukraine.

Lesya Mamontova
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Vasylkivska Street 45, Kiev 03022, Ukraine.

Sergej Merentsev
City Clinical Oncological Center, Verchovynna Street 69, Kiev 03115, Ukraine.

Professor Sergej Osinsky
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Vasylkivska Street 45, Kiev 03022, Ukraine.

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