Compact RF/ Laser Dielectric Linacs for Internal and External Cancer Therapy and Dynamic DNA Damage/Repair Analysis | Chapter 15 | Recent Developments in Engineering Research Vol. 12

 We are performing three-staged development of compact linear accelerators (hereafter linac) with Sband (2.856 GHz, wavelength 105 mm), X-band (9.3 GHz, 32.3 mm) RF (Radio frequency) and Yb fiber laser (283 THz, wavelength 1.06 mm). Recently, we have proposed S-band 40 MeV 40 kW linac for Medical RI (Radioisotope) production of 99Mo/99mTc (g -emitter), 67Cu (b +) and 225Ac (a). X-band 6 MeV linacs have been developed for cancer therapy using pinpoint X-ray dynamic tracking. The size of the electron beam at the X-ray target is less than 1 mm, and the size of the X-ray spot at the cancer is less than 3 mm. Several pieces of hardware and software are being developed for dynamic tracking radiation therapy (RT) for moving lung cancer. Furthermore, as the ultimate compact linac, we are designing and manufacturing a 1 MeV laser dielectric linac with Yb fiber laser. Because the wavelength is 1.06 m long, the length of one The accelerating structure is tens of meters long, and the electron beam is one meter long. We intend to use this “On-chip” linac for radiation-induced DNA damage/repair analysis because the cell and nucleus sizes are approximately 10 and 1 m, respectively. We are considering a system in which DNA in a cell nucleus is hit by 1 m electron- and ion-beams and its repair by proteins and enzymes in live cells is observed in-situ. Finally, we strive to make a contribution to advanced radiation biological research for theranostics (= therapeutics and diagnostics).

 Author(s) Details

M. Uesaka
Nuclear Professional School/Department of Nuclear Engineering and Management, 2-22 Shirakata-shirane, Tokai, Naka, Ibaraki, 319-1106, Japan.

M. Pohl
Nuclear Professional School/Department of Nuclear Engineering and Management, 2-22 Shirakata-shirane, Tokai, Naka, Ibaraki, 319-1106, Japan.

K. Miyoshi
Nuclear Professional School/Department of Nuclear Engineering and Management, 2-22 Shirakata-shirane, Tokai, Naka, Ibaraki, 319-1106, Japan.

Y. Inoue
Nuclear Professional School/Department of Nuclear Engineering and Management, 2-22 Shirakata-shirane, Tokai, Naka, Ibaraki, 319-1106, Japan.

T. Takahashi
Nuclear Professional School/Department of Nuclear Engineering and Management, 2-22 Shirakata-shirane, Tokai, Naka, Ibaraki, 319-1106, Japan.

M. Ozeki
Nuclear Professional School/Department of Nuclear Engineering and Management, 2-22 Shirakata-shirane, Tokai, Naka, Ibaraki, 319-1106, Japan.

S. Kamei
Nuclear Professional School/Department of Nuclear Engineering and Management, 2-22 Shirakat shirane, Tokai, Naka, Ibaraki, 319-1106, Japan.

J. Jang
Metal Technology, 713 Narihira, Shaka, Ebiba, Kanagawa 243-0424, Japan.

M. Yoshida
High Energy Accelerator Development Organization, 1-1 Oho, Tsukuba, Ibrakaki, 305-0810, Japan.


K. Koyama
High Energy Accelerator Development Organization, 1-1 Oho, Tsukuba, Ibrakaki, 305-0810, Japan.

T. Ikeda
RIKEN, 2-1 Hirokawa, Wako, Saitama 351-0198, Japan.

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