Handigodu Disease (HD) is a condition of the osteoarticular system that is quite common in many villages of two districts in Karnataka, southern India: Shimoga and Chikmaglur. It's an osteoarthritis condition that's both rare and painful. Spondylo-epi- (meta)physeal Dysplasia, Autosomal Dominant variant, Handigodu syndrome is the scientific name for the condition. The same categorization is used in the International Classification of Skeletal Dysplasias. There was no calcium homeostasis research in HD. Serum calcium, phosphorus, parathyroid hormone, and calcitonin levels, as well as calcium and phosphorus urinary excretion, were monitored for 24 hours after an overnight fast. There was a drop in calcitonin levels in HD, which was linked to a decrease in serotonin levels. In HD patients, urine phosphorus remains constant. Vitamin D3 levels in HD patients were also found to be unaffected. Because calcitonin has an antiresorption impact on bone, low calcitonin levels in HD may indicate bone resorption, which can lead to deformity, hypocalcaemia, and hypocalciuria. Hypocalcitonemia combined with hypocalcaemia without a change in iPTH could be caused It's possible that hypocalcaemia is caused by a mutation in the Vit D receptor (VDR) or that it's an epiphenomenon.
Author (S) Details
Mallikarjun Badadani
Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore-560029, India.
K. Taranath Shetty
Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore-560029, India.
S. S. Agarwal
Advanced Center for Treatment Research and Education in Cancer (ACTREC), Navi Mumbai, India.
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